Results 121 to 130 of about 11,482,458 (388)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Organic Radical-Boosted Ionic Conductivity in Redox Polymer Electrolyte for Advanced Fiber-Shaped Energy Storage Devices

Nano-Micro Letters
Highlights Developed a versatile HT-based redox polymer electrolyte with exceptional ionic conductivity (73.5 mS cm−1) through self-exchange reaction-based ion hopping mechanism and enhanced polymer chain mobility.
Jeong-Gil Kim, Jaehyoung Ko, Hyung-Kyu Lim, Yerin Jo, Hayoung Yu, Min Woo Kim, Min Ji Kim, Hyeon Su Jeong, Jinwoo Lee, Yongho Joo, Nam Dong Kim   +10 more
doaj   +1 more source

Bending Behavior Analysis of Box Beams with the Reinforcement of Composite Materials for Wind Turbine Blades [PDF]

, 2023
Ofelia Maldonado-Santiago, J.B. Robles-Ocampo, Eduardo Gálvez, P.Y. Sevilla-Camacho, Sergio de la Cruz, Juvenal Rodríguez‐Reséndiz, Edwin Hernández   +6 more
openalex   +1 more source

Flame-retardant composite materials [PDF]

The properties of eight different graphite composite panels fabricated using four different resin matrices and two types of graphite reinforcement are described. The resin matrices included: VPSP/BMI, a blend of vinylpolystyryl pyridine and bismaleimide;
Kourtides, Demetrius A.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Ablation resistance of C/C-HfC composites

Cailiao gongcheng
C/C-HfC composites with a density of 2.14 g/cm3 was successfully prepared using an inorganic hafnium solution as a precursor via chemical vapor infiltration (CVI) and precursor infiltration pyrolysis (PIP) methods, and its microstructure and composition ...
ZHENG Peng, LI Hong, YANG Min, YAO Yumin, REN Musu, SUN Jinliang   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Experimental and numerical polar scans of several anisotropic materials using pulsed and harmonic ultrasonic beams [PDF]

, 2011
Ultrasonic non-destructive testing is a well known technique in present days, in which the C-scan is the most wide spread. Though, because of the inherent limitations of most methods to quantitatively characterize (damaged) composite materials, the quest
De Baere, Ives, Degrieck, Joris, Gu, Jun, Kersemans, Mathias, Sol, Hugo, Van Paepegem, Wim, Zastavnik, Filip   +6 more
core  

Measure of combined effects of morphological parameters of inclusions within composite materials via stochastic homogenization to determine effective mechanical properties

, 2015
In our previous papers we have described efficient and reliable methods of generation of representative volume elements (RVE) perfectly suitable for analysis of composite materials via stochastic homogenization.
Choï, Daniel, Karamian-Surville, Philippe, Lemaitre, Sophie, Salnikov, Vladimir   +3 more
core   +3 more sources