Results 71 to 80 of about 124,379 (246)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Experimental Study on the Force Mechanism of Internal Composite Connectors in Steel–Concrete Composite Sections of Bridge Towers

Buildings
Current research on the stress mechanisms of composite connectors within steel–concrete structures of bridge towers is sparse, and there is a lack of established experimental methods and finite element modeling techniques for studying these mechanisms ...
Yunwei Du, Zhenqing Yu, Yuyang Chen, Niujing Ma, Ronghui Wang   +4 more
doaj   +1 more source

Withdrawal of 'Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation'. [PDF]

Mol Cell Proteomics, 2023
Pyke RM, Mellacheruvu D, Dea S, Abbott CW, Zhang SV, Phillips NA, Harris J, Bartha G, Desai S, McClory R, West J, Snyder MP, Chen R, Boyle SM.   +13 more
europepmc   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Research on the Dynamic Modeling of Rigid–Flexible Composite Spacecraft Under Fixed Constraints Based on the ANCF

Aerospace
Dynamically modeling the flexible characteristics of large-scale jointed composite spacecraft is challenging. In this study, a dynamic modeling method for rigid–flexible composite spacecraft is proposed based on the absolute nodal coordinate formulation (
Jiaqi Wu, Guohua Kang, Junfeng Wu, Chuanxiao Xu, Jiayi Zhou, Xinyong Tao, Yinmiao Hua   +6 more
doaj   +1 more source

Precision Neoantigen Discovery Using Large-Scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation. [PDF]

Mol Cell Proteomics, 2023
Pyke RM, Mellacheruvu D, Dea S, Abbott C, Zhang SV, Phillips NA, Harris J, Bartha G, Desai S, McClory R, West J, Snyder MP, Chen R, Boyle SM.   +13 more
europepmc   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Mathematical Modelling of the Process of Spark Plasma Sintering of a Ceramic Material Composite Al2O3 - ZrO2 - Y2O3, Modified by Carbon Nanotubes

Chemical Engineering Transactions, 2018
Experimental studies have been carried out in the field of obtaining carbon nanotubes (CNT) and Al2O3 - ZrO2 - Y2O3 composite reinforced with CNTs. Mathematical models of CNT synthesis and spark plasma sintering of a composite have been developed. On the
Natasha V. Mamonova, Eleonora M. Koltsova, Evgenia A. Skichko, Anna S. Shaneva, Nelly A. Popova   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source