Results 71 to 80 of about 81,515 (311)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Stochastic Response of Composite Post Insulators under Seismic Excitation

Buildings
Composite post insulators are crucial facilities in substations and are prone to significant damage during seismic disasters. However, existing research lacks seismic motion models suitable for power facilities and rarely involves stochastic models ...
Haibo Wang, Yongfeng Cheng, Zhicheng Lu, Ronghua Huan, Qiangfeng Lü, Zhenlin Liu   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modelling and simulation study on dynamic pollution accumulation process of composite insulator

High Voltage
With the widespread application of composite insulators in transmission lines, exploring the accumulation mechanism of pollution particles on composite insulator surfaces is of importance to ensure the safe and steady operation of the power system ...
Zhongyi Yang, Dongxiong Liu, Xiangjun Zeng, Caijin Fan, Xin Yang, Yafei Huang   +5 more
doaj   +1 more source

Floating Behavior of a Composite Bucket Foundation under the Combined Action of Wind and Waves

Journal of Marine Science and Engineering, 2022
In this study, a composite bucket foundation (CBF) was investigated by taking into account the reflection and refraction effects of waves. A numerical model for the motion responses of the structure under different wave heights and wave periods was built
Xing Zhao, Puyang Zhang, Conghuan Le, Hongyan Ding   +3 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Experimental and numerical studies on low velocity impacts detection and damage identification in metal and composite structures using ultrasonic waves propagation (Lamb waves) [PDF]

, 2011
In this thesis a theoretical base required for the development of a reliable structural health monitoring system based on ultrasonic guided waves is considered.
Tancredi, Simone
core  

Modeling and Dynamical Behavior of Rotating Composite Shafts with SMA Wires

Shock and Vibration, 2014
A dynamical model is developed for the rotating composite shaft with shape-memory alloy (SMA) wires embedded in. The rotating shaft is represented as a thin-walled composite of circular cross-section with SMA wires embedded parallel to shaft’s ...
Yongsheng Ren, Qiyi Dai, Ruijun An, Youfeng Zhu   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source