Results 91 to 100 of about 81,515 (311)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reliability and Validity Examination of a New Gait Motion Analysis System

Sensors
Recent advancements have made two-dimensional (2D) clinical gait analysis systems more accessible and portable than traditional three-dimensional (3D) clinical systems.
Tadamitsu Matsuda, Yuji Fujino, Tomoyuki Morisawa, Tetsuya Takahashi, Kei Kakegawa, Takanari Matsumoto, Takehiko Kiyohara, Hiroshi Fukushima, Makoto Higuchi, Yasuo Torimoto, Masaki Miwa, Toshiyuki Fujiwara, Hiroyuki Daida   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Simulated Cam Morphology of the Hip Changes Sacroiliac Motion During Hip Motion and Loading in a Cadaveric Model

Arthroscopy, Sports Medicine, and Rehabilitation
Purpose: To determine the relationship between cam morphology of the hip and ipsilateral sacroiliac motion compared to the native hip in a cadaveric model.
Mason E. Uvodich, M.D., Alex W. Hooke, M.A., Zachary V. Braig, M.D., Micah J. Nieboer, M.D., Evan M. Dugdale, M.D., William W. Cross, M.D., Aaron J. Krych, M.D., Mario Hevesi, M.D., Ph.D.   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Calculation and analysis of meshing efficiency of composite motion of the curve-face gear pairs [PDF]

, 2019
The curve-face gear is a new type of composite motion mechanism. The calculation of meshing efficiency of composite motion is proposed in this paper. According to the gear meshing principle, the force state of the curve-face gear pair and the motion law ...
Xing, Qingkun, Liu, Wensi, Tang, Pei, Xia, Xiguang, Lin, Chao   +4 more
core   +2 more sources

Mechanically Tunable Composite Hydrogel for Multi-Gesture Motion Monitoring

Biosensors
Intrinsic conductive ionic hydrogels, endowed with excellent mechanical properties, hold significant promise for applications in wearable and implantable electronics.
Jiabing Zhang, Zilong He, Bin Shen, Jiang Li, Yongtao Tang, Shuhuai Pang, Xiaolin Tian, Shuang Wang, Fengyu Li   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Facial motion perception in autism spectrum disorder and neurotypical controls [PDF]

, 2015
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University LondonFacial motion provides an abundance of information necessary for mediating social communication.
Girges, Christine, Christine Girges
core