Results 111 to 120 of about 81,515 (311)

Geometry generation principle and meshing properties of a new gear drive

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
The generation principle of composite cycloid is proposed for the tooth profile of external drive. Firstly, a two-link mechanism is developed as the equivalent mechanism to describe the geometric principle of cycloid by introducing the motion ...
Zhenhua HAN, Wankai SHI, Chang LIU, Lang XU   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Nonlinear Dynamics of the High-Speed Rotating Plate

International Journal of Aerospace Engineering, 2018
High speed rotating blades are crucial components of modern large aircraft engines. The rotating blades under working condition frequently suffer from the aerodynamic, elastic and inertia loads, which may lead to large amplitude nonlinear oscillations ...
Minghui Yao, Li Ma, Wei Zhang
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Design of Computer Numerical Control System for Fiber Placement Machine Based on Siemens 840D sl

Sensors
To address the manufacturing demands of large-scale aerospace composite components, this study systematically investigates the coordinated motion characteristics of multi-axis systems in fiber placement equipment.
Kun Xia, Di Zhao, Qingqing Yuan, Jingxia Wang, Aodong Shen   +4 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Scaling limit for the random walk on the largest connected component of the critical random graph [PDF]

, 2012
In this article, a scaling limit for the simple random walk on the largest connected component of the Erdos-Rényi random graph G(n,p) in the critical window, p = n−1+λn−4/3, is deduced.
Croydon, David A.
core   +1 more source

A Novel Flow Characteristic Regulation Method for Two-Stage Proportional Valves Based on Variable-Gain Feedback Grooves

Machines
The two-stage proportional valve is a key control component in heavy-duty equipment, where its signal-flow characteristics critically influence operational performance.
Xingyu Zhao, Huaide Geng, Long Quan, Chengdu Xu, Bo Wang, Lei Ge   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source