Results 101 to 110 of about 582,363 (267)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A comparative study on milling-induced surface roughness during milling of jute–epoxy and carbon–epoxy composites and optimization for better surface finish through Taguchi and RSM techniques

AIP Advances
During the present experimentation, milling machining was performed on two different composites, namely carbon fiber-reinforced polymer composite and jute fiber-reinforced polymer composite, using a computer numerical control vertical machining center ...
Murthy B. R. N., Anupama Hiremath, Jayant Giri, Emad Makki, Sathish T., Gururaj Bolar, Vishwanatha H. M.   +6 more
doaj   +1 more source

A Stefan problem for composite materials with an arbitrary number of moving phase-transition boundaries

Учёные записки Казанского университета: Серия Физико-математические науки
A Stefan problem of heat transfer in semi-infinite bodies with an arbitrary number of unsteady moving boundaries during phase transitions was solved. Such problems arise when composite materials are heated at high temperatures, causing the binding agents
E. L. Kuznetsova, S. I. Zhavoronok
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

弹性复合圆柱滚子轴承动态径向刚度分析

Jixie chuandong, 2014
According to the basic structure characteristics of elastic composite cylindrical roller bearing,researches on dynamic radial stiffness of elastic composite cylindrical roller bearing are carried out in detail.The finite element analysis software is ...
姚齐水, 张然, 余江鸿, 杨文
doaj  

Highly Composite Numbers [PDF]

Proceedings of the London Mathematical Society, 1915
openaire   +1 more source

Counting Composite and Prime Numbers

, 2020
Abstract: The set of positive integers can be divided into different sub-sets, such as the sets of even numbers, of odd numbers, of primes and of composites. Unlike the patterns for even numbers and odd numbers, no repetitive pattern has been identified for readily locating all the primes within the number line and hence by definition to readily locate
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source