Results 151 to 160 of about 566,663 (314)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Improvement of the anti-debonding performance of CFRP-steel circular hollow section with conical-shaped CHS under tensile load: a finite element analysis. [PDF]

Sci Rep
Wang QZ, Guo Y, Chang Y, Wei YH, Ma KJ, Tian PG, Zhao BZ, Liu ZQ.   +7 more
europepmc   +1 more source

Calculating cost per event avoided using a composite number needed to treat

Joshua C. Toliver, J. Wang, Jigish Bhavsar, Sean D. Sullivan   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Composite numbers V

Applied Mathematical Sciences, 2019
openaire   +1 more source

A Geometric Model of Prime Number Distribution Based on the Quadratic Structure of Composite Numbers

Sergey Srynnik
openalex   +2 more sources

Measuring and evolution analyzing of the reliability in urban public transport composite network. [PDF]

PLoS One
Luo Q, Yu H, Yang L, Gao T.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Use of Amalgam and Composite Restorations Among 12-Year-Old Children in Israel: A Retrospective Study. [PDF]

Biomimetics (Basel)
Nassar R, Chackartchi T, Doron H, Mann J, Findler M, Tobias G.   +5 more
europepmc   +1 more source

On stress-strain state of a non-homogeneous composite in form of a package composed of an arbitraryfinite number of elastic wedges under anti-plain deformation.

, 2014
A. V. Gasparyan, Zaven Davtyan
openalex   +1 more source