Results 41 to 50 of about 453,515 (291)

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Harnessing machine learning approach for hardness optimization of Al-Si alloy composites reinforced with coconut shell ash

Materials Research Express
Purpose . The purpose of this study was to utilize Machine Learning (ML) to optimize the hardness of aluminum-silicon (Al-Si) alloy composites reinforced with Coconut Shell Ash (CSA).
M Poornesh, Shreeranga Bhat, Mithun Kanchan   +2 more
doaj   +1 more source

On a novel approach for optimizing composite materials panel using surrogate models [PDF]

, 2011
This paper describes an optimization procedure to design thermoplastic composite panels under axial compressive load conditions. Minimum weight is the goal. The panel design is subject to buckling constraints.
Akcay-Perdahcioglu, D., Boer, A. de, De Guido, S., Geijselaers, H.J.M.   +3 more
core   +1 more source

Stochastic Compositional Optimization with Compositional Constraints

INFORMS Journal on Optimization
Stochastic compositional optimization (SCO) has attracted considerable attention because of its broad applicability to important real-world problems. However, existing work on SCO typically assumes that the projection within a solution update is straightforward, which is not the case for problem instances where constraints are in the form of ...
Shuoguang Yang, Wei You, Zhe Zhang, Ethan X. Fang   +3 more
openaire   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Optimum Design of UAV Wing Skin Structure with a High Aspect Ratio Using Variable Laminate Stiffness

Applied Sciences, 2022
This paper quickly calculated the design variables to satisfy the strength and stability conditions, the dominant design verification conditions of the composite wing structure, through a genetic algorithm.
Jun-Hwan Jang, Sang-Ho Ahn
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Optimized dynamic semantic composition of services [PDF]

Proceedings of the 2008 ACM symposium on Applied computing, 2008
This paper proposes a design for the optimized dynamic (re)composition of services that supports various user requests and accounts for changes in user's context. The composition mechanism relies on semantic descriptions of services' functionality to compose services at runtime.
Sorin M. Iacob, João Paulo A. Almeida, Maria-Eugenia Iacob   +2 more
openaire   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source