Results 61 to 70 of about 109,850 (269)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Compositional optimization of disjunctive abstract interpretations [PDF]
, 1996 We define the inverse operation for disjunctive completion, introducing the notion of least disjunctive basis for an abstract domain D: this is the most abstract domain inducing the same disjunctive completion as D. We show that the least disjunctive basis exists in most cases, and study its properties in relation with reduced product of abstract ...
GIACOBAZZI R., RANZATO, FRANCESCO
openaire +2 more sources
Geometric optimization via composite majorization [PDF]
ACM Transactions on Graphics, 2017 Many algorithms on meshes require the minimization of composite objectives, i.e. , energies that are compositions of simpler parts. Canonical examples include mesh parameterization and deformation. We propose a second order optimization approach that exploits this composite structure to efficiently converge to a ...
Anna Shtengel +4 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Composite Optimization by Nonconvex Majorization-Minimization [PDF]
SIAM Journal on Imaging Sciences, 2018 38 pages, 12 figures, accepted for publication in ...
Jonas Geiping, Michael Möller 0001
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Multi-objective optimization of composite plates using lamination parameters
Materials & Design, 2019 Laminated composite plates are extensively used in various industries due to their high stiffness-to-weight ratio and directional properties that allow optimization of the stiffness characteristics for specific applications.
Gokhan Serhat, Ipek Basdogan
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Optimization of multispan ribbed plywood plate macrostructure for multiple load cases
Journal of Civil Engineering and Management, 2013 This paper discusses an optimized structural plate of plywood composite that consists of top and bottom plywood flanges and a core of plywood ribs. The objective function is structure's weight.
Jānis Šliseris, Kārlis Rocēns
doaj +1 more source
Fracture and Structural Integrity, 2020 Composite materials are most often used for lengthier and thin structures susceptible to buckle. The optimization is often carried out taking into consideration the resistance to buckling and tensile loads for minimum displacement i.e maximization of the
Fouzia Merabbi +3 more
doaj +1 more source