Results 71 to 80 of about 453,515 (291)

Novel Aspect of Composite Sandwich Fairing Structure Optimization of a Two Stages Launch Vehicle by Using MDO Independent Subspace Approach [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2018
In this paper, a novel composite sandwich structure analysis of Launch Vehicle (LV) fairing is considered and proposed by a new Multidisciplinary Design Optimization (MDO) for a two-stage launch vehicle.
Foozie Morovat, Jafar Roshanian, Ali Mozaffari, Hadi Zaare   +3 more
doaj  

Stochastic Intermediate Gradient Method for Convex Problems with Inexact Stochastic Oracle [PDF]

, 2015
In this paper we introduce new methods for convex optimization problems with inexact stochastic oracle. First method is an extension of the intermediate gradient method proposed by Devolder, Glineur and Nesterov for problems with inexact oracle.
Dvurechensky, Pavel, Gasnikov, Alexander
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Douglas-Rachford Splitting: Complexity Estimates and Accelerated Variants

, 2014
We propose a new approach for analyzing convergence of the Douglas-Rachford splitting method for solving convex composite optimization problems. The approach is based on a continuously differentiable function, the Douglas-Rachford Envelope (DRE), whose ...
Bemporad, Alberto, Patrinos, Panagiotis, Stella, Lorenzo   +2 more
core   +1 more source

Optimized methods for composite optimization: a reduction perspective

CoRR
Recent advances in convex optimization have leveraged computer-assisted proofs to develop optimized first-order methods that improve over classical algorithms. However, each optimized method is specially tailored for a particular problem setting, and it is a well-documented challenge to extend optimized methods to other settings due to their highly ...
Jinho Bok, Jason M. Altschuler
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Performance-based optimization of structures: theory and applications [PDF]

, 2005
Performance-based Optimization of Structures introduces a method to bridge the gap between optimization theory and its practical applications to structural engineering.
Liang, Qing Quan
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Validation of effect of composite additive on optimized combustion characteristics of CI engine using AHP and GRA method

Heliyon
The primary focus of this study is the validation of composite additives with the help of additional optimization methods and the analysis of its effect on the combustion characteristics of compression ignition (CI) engines.
Amit R. Patil, S.A. Patil, Rupali Patil, A.M. Pawar, V.N. Chougule, Kareem AboRas   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source