Results 71 to 80 of about 109,850 (269)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimized methods for composite optimization: a reduction perspective

Mathematical Programming
Abstract Recent advances in convex optimization have leveraged computer-assisted proofs to develop optimized first-order methods that improve over classical algorithms. However, each optimized method is specially tailored for a particular problem setting, and it is a well ...
Jinho Bok, Jason M. Altschuler
openaire   +2 more sources

Design and Optimization of Floor Layers in Carbon Fiber Composites for Body‐in‐White Materials

Engineering Reports
To improve the performance of the body‐in‐white (BIW) and achieve automotive lightweighting, a balanced approach across materials, techniques, and structures is required to save costs.
Guang Zhu, Wenjie Xiao, Shuai Zhang, Xiaobo An, Changye Zhao   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Research on cost and carbon reduction using the optimization of composite slabs modules based on bim technology

Scientific Reports
As one of the primary precast components in prefabricated construction, composite slabs have increasingly attracted interest for their costs as well as carbon footprint in production and installation stages.
Huo Haie, Liu Mingrong, Zhou Juncen
doaj   +1 more source

Novel Aspect of Composite Sandwich Fairing Structure Optimization of a Two Stages Launch Vehicle by Using MDO Independent Subspace Approach [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2018
In this paper, a novel composite sandwich structure analysis of Launch Vehicle (LV) fairing is considered and proposed by a new Multidisciplinary Design Optimization (MDO) for a two-stage launch vehicle.
Foozie Morovat, Jafar Roshanian, Ali Mozaffari, Hadi Zaare   +3 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Validation of effect of composite additive on optimized combustion characteristics of CI engine using AHP and GRA method

Heliyon
The primary focus of this study is the validation of composite additives with the help of additional optimization methods and the analysis of its effect on the combustion characteristics of compression ignition (CI) engines.
Amit R. Patil, S.A. Patil, Rupali Patil, A.M. Pawar, V.N. Chougule, Kareem AboRas   +5 more
doaj   +1 more source