Results 81 to 90 of about 109,850 (269)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Program Composition and Optimization: An Introduction

, 2010
Software composition connects separately defined software artifacts. Such connection may be in program structure (such as inheritance), data flow (such as message passing) and/or control flow (such as function calls or loop control).
Kessler, Christoph W., Löwe, Welf, Padua, David, Püschel, Markus   +3 more
openaire   +4 more sources

Stacking sequence optimization of composite laminates for maximum fundamental frequency using Bayesian optimization computational framework

Results in Engineering
A computational framework combined with the commercial finite element software Abaqus and Bayesian optimization algorithm is proposed. The proposed computational framework leverages the Gaussian process based-probabilistic capability in Bayesian ...
Shih-Ting Yang, Yu-Jui Liang
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Multiobjective Optimization of Composite Material Seat Plate for Mortar Based on the Hybrid Surrogate Model

Shock and Vibration
As an important force transmission component of mortars, the seat plate affects some core indicators of mortars such as range, shooting accuracy, and maneuverability.
Fengfeng Wang, Chundong Xu, Lei Li
doaj   +1 more source

An Improved Ant Colony Model for Cost Optimization of Composite Beams

Applied Artificial Intelligence, 2017
This paper focused on the application and evaluation of an improved ant colony search method for the cost optimization of composite beams. The design was based on the American Institute of Steel Construction load and resistance factor design ...
Tahereh Korouzhdeh, Hamid Eskandari-Naddaf, Morteza Gharouni-Nik   +2 more
doaj   +1 more source

Parameter Optimization for Composite Structures of Microperforated Panel and Porous Metal for Optimal Sound Absorption Performance

Applied Sciences, 2019
The composite structure of a microperforated panel and porous metal is a promising sound absorber for industrial noise reduction, sound absorption performance of which can be improved through parameter optimization. A theoretical model is constructed for
Haiqin Duan, Xinmin Shen, Fei Yang, Panfeng Bai, Xiaofang Lou, Zhizhong Li   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

THE GENERALIZED CONSTRUCTIVE FORM OF TWO-PYLON CABLE-STAYED COMPOSITE BRIDGES AND THE FLOW-CHART OF PROGRAM OF THEIR DESIGN OPTIMIZATION

Structural Mechanics of Engineering Constructions and Buildings, 2010
This article presents the generalized constructive form of two-pylon cable-stayed composite bridges and the flow - chart of program of design optimization that provides the basis for developing the corresponding program of design optimization. KEY
P M Salamahin, - Le Van Manh
doaj  

VisCI: A visualization framework for anomaly detection and interactive optimization of composite index

Visual Informatics
Composite index is always derived with the weighted aggregation of hierarchical components, which is widely utilized to distill intricate and multidimensional matters in economic and business statistics.
Zhiguang Zhou, Yize Li, Yuna Ni, Weiwen Xu, Guoting Hu, Ying Lai, Peixiong Chen, Weihua Su   +7 more
doaj   +1 more source