Results 101 to 110 of about 453,515 (291)

Optimal design for continuous composite slabs via metaheuristic algorithms

REM: International Engineering Journal
With the increase in greenhouse gas emissions from the construction sector, pursuing more sustainable solutions has become essential. The use of composite steel-concrete slabs can considerably reduce environmental impacts due to their rapid construction ...
Mariana Oliveira Teixeira, Élcio Cassimiro Alves, Janaina Pena Soares de Oliveira Valle, Adenilcia Fernanda Grobério Calenzani   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Optimal design of composite hip implants using NASA technology [PDF]

Using an adaptation of NASA software, we have investigated the use of numerical optimization techniques for the shape and material optimization of fiber composite hip implants.
Blake, T. A., Davy, D. T., Hopkins, D. A., Saravanos, D. A., Waters, S. A.   +4 more
core   +1 more source

Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate. [PDF]

Pharmaceuticals (Basel), 2022
Zaki RM, Alfadhel MM, Alfadhel MM, Alossaimi MA, Elsawaf LA, Devanathadesikan Seshadri V, Almurshedi AS, Yusif RM, Said M.   +8 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Decentralized Primal-Dual Proximal Operator Algorithm for Constrained Nonsmooth Composite Optimization Problems over Networks. [PDF]

Entropy (Basel), 2022
Feng L, Ran L, Meng G, Tang J, Ding W, Li H.   +5 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Optimized alloy composition

, 2020
Summary of deliverable D2.1. The increase in air pollution and global temperatures demonstrates how essential it is to look for alternatives to fossil fuels. The efficient storage of renewable energy would enable the transition towards CO2-free energy. Hydrogen can be produced from renewable sources and, as an efficient energy carrier, it can be stored
Dematteis, Erika Michela, Cuevas, Fermin, Latroche, Michel   +2 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

An integrated methodology for optimizing structural composite damping [PDF]

A method is presented for tailoring plate and shell composite structures for optimal forced damped dynamic response. The damping of specific vibration modes is optimized with respect to dynamic performance criteria including placement of natural ...
Chamis, C. C., Saravanos, D. A.
core   +1 more source