Results 111 to 120 of about 453,515 (291)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Zhongguo dianliThe reasonable planning and configuration of composite system in low-carbon park is of great significance for improving system energy efficiency and reducing costs and pollutant emissions.
Yang WANG +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Energy Material AdvancesMetal–organic frameworks have emerged as promising electrode materials for metal-ion batteries due to their superior structural customizability. However, they face challenges such as poor reversibility and easy degradation during electrochemical redox ...
Zaohong Zhang +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Stability optimization of laminated composite plates [PDF]
The optimum design of plates with orthotropic layers under axial compression and shear is discussed. The plates considered are the laminates of N orthotropic layers whose principal material axes coincide with the plate axes. Each layer is assumed to have
Hirano, Y.
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Multi-objective fuzzy optimization of sizing and location of piezoelectric actuators and sensors for vibration control based on the particle swarm optimization technique: Part 2: Numerical analysis [PDF]
Scientific Technical Review, 2014 This is the second part of a two-paper research of the multi-objective fuzzy optimization of sizing and location of the collocated piezoelectric actuators and sensors on the thin-walled composite beam. The first paper is focussed on the theoretical model
Zorić Nemanja +5 more
doaj
Numerical analysis of repaired wall loss defect pipelines for optimum composite wrap thickness
Fracture and Structural Integrity, 2022 The paper presents the numerical analysis of failure pressure of wall loss defect metallic pipelines and validate it with experimental results. An optimization of composite thickness for repair of wall loss defect pipeline is also carried out using ...
Muhammed Khaise +4 more
doaj