Results 151 to 160 of about 387,107 (263)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Carbon emission analysis and evaluation of steel-concrete composite structure bridge based on fuzzy comprehensive evaluation comprehensive evaluation method. [PDF]

Sci Prog
Li Y, Qiao W, Yang F, Zhou T, Quan H.
europepmc   +1 more source

Study on Forming Law and Penetration of a Spherical Cone Composite Structure Liner Based on the Explosion Pressure-Coupling Constraint Principle. [PDF]

Materials (Basel), 2022
Han J, Du Z, Zheng C, Wang Y, Shang Y, Huang W, Wang X, Zhao J.   +7 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

High-Energy Low-Velocity Impact Behavior of Rubber-Coated Sandwich Composite Structure with Buoyancy Material Core: Experimental and Numerical Investigation. [PDF]

Materials (Basel)
Zhu Y, Mei Z, Li H, Tao H, Chen G.
europepmc   +1 more source

Synthesis and Characterization of Sn/SnO₂/C Nano-Composite Structure: High-Performance Negative Electrode for Lithium-Ion Batteries. [PDF]

Materials (Basel), 2022
Saddique J, Shen H, Ge J, Huo X, Rahman N, Mushtaq M, Althubeiti K, Al-Shehri H.   +7 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Facile Synthesis of MoP and Its Composite Structure with Ru as an Efficient Electrocatalyst for Hydrogen Evolution Reaction in Both Acidic and Alkaline Conditions. [PDF]

Materials (Basel)
Ren P, Wang R, Yang Y, Wang T, Hong Y, Zheng Y, Zheng Q, Ren X, Jia Z.   +8 more
europepmc   +1 more source

Experimental and Numerical Analysis of Multiple Low-Velocity Impact Damages in a Glass Fibered Composite Structure. [PDF]

Materials (Basel), 2021
Balasubramaniam K, Ziaja D, Jurek M, Fiborek P, Malinowski P.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source