Results 171 to 180 of about 9,422,830 (251)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

NO₂ Gas Sensor Based on WO₃/SiNWs Composite Structure. [PDF]

Micromachines (Basel)
Sun F, Zhang E.
europepmc   +1 more source

Advanced Nanomechanical Characterization of Biopolymer Films Containing GNPs and MWCNTs in Hybrid Composite Structure. [PDF]

Nanomaterials (Basel), 2022
Batakliev T, Ivanov E, Angelov V, Spinelli G, Kotsilkova R.   +4 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The Fracture Mechanism of Impact-Resistant Bionic 3D Model Structures Inspired by Composite Structure of Mantis Shrimp Appendage. [PDF]

Biomimetics (Basel)
Yang X, Meng M, Meng X, Huang A, Shao C, Wang Y, Jin H.   +6 more
europepmc   +1 more source

Novel Technique for Design and Manufacture of Alternating Gradient Composite Structure of Aluminum Alloys Using Solid State Additive Manufacturing Technique. [PDF]

Materials (Basel), 2022
Venkit H, Selvaraj SK.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Composite Structure as a Stress Wave Barrier Zone Under Impulse Loading: Microscale Numerical Analysis of Attenuation. [PDF]

Materials (Basel)
Murčinková Z, Sabol D, Baron P.
europepmc   +1 more source

Bioinspired Helicoidal Composite Structure Featuring Functionally Graded Variable Ply Pitch. [PDF]

Materials (Basel), 2021
Meo M, Rizzo F, Portus M, Pinto F.
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source