Results 181 to 190 of about 8,042,329 (290)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Non-linear analysis of multi-span composite beams under combined flexure and torsion

, 2015
Multi-span steel-concrete composite beams fabricated from two steel joists and one concrete slab are widely utilised in bridges and highway interchanges, and are commonly subjected to combined actions of flexure and torsion.
Uy, Brian, Tan, Ee Loon (R14425), Ban, Huiyong   +2 more
core  

Carbon emission analysis and evaluation of steel-concrete composite structure bridge based on fuzzy comprehensive evaluation comprehensive evaluation method. [PDF]

Sci Prog
Li Y, Qiao W, Yang F, Zhou T, Quan H.
europepmc   +1 more source

Study on Forming Law and Penetration of a Spherical Cone Composite Structure Liner Based on the Explosion Pressure-Coupling Constraint Principle. [PDF]

Materials (Basel), 2022
Han J, Du Z, Zheng C, Wang Y, Shang Y, Huang W, Wang X, Zhao J.   +7 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

High-Energy Low-Velocity Impact Behavior of Rubber-Coated Sandwich Composite Structure with Buoyancy Material Core: Experimental and Numerical Investigation. [PDF]

Materials (Basel)
Zhu Y, Mei Z, Li H, Tao H, Chen G.
europepmc   +1 more source

Antibiotic cement plate composite structure internal fixation after debridement of bone infection. [PDF]

Sci Rep, 2021
Wang X, Wang S, Xu J, Sun D, Shen J, Xie Z.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Experimental and Numerical Analysis of Multiple Low-Velocity Impact Damages in a Glass Fibered Composite Structure. [PDF]

Materials (Basel), 2021
Balasubramaniam K, Ziaja D, Jurek M, Fiborek P, Malinowski P.   +4 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source