Results 41 to 50 of about 2,631 (286)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
A more natural composite Higgs model
Journal of High Energy Physics, 2020 Composite Higgs models provide an attractive solution to the hierarchy problem. However, many realistic models suffer from tuning problems in the Higgs potential. There are often large contributions from the UV dynamics of the composite resonances to the
Hsin-Chia Cheng, Yi Chung
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
31305: Tevatron searches for compositeness [PDF]
, 1997 Tevatron experiments have recently set or improved limits on quark and lepton compositeness. Included here are results from {radical}s = 1.8 TeV p{anti p} collider experiments D0 and CDF and from fixed target neutrino experiment CCFR, who report limits ...
Gallas, E. +1 more
core
Underlying gauge-fermion models of compositeness [PDF]
, 2021 We review recent advances in the construction of models of compositeness using four-dimensional gauge theories with fermionic matter. We discuss the group theory data needed to fulfill the basic phenomenological requirements and we touch upon the main ...
Ferretti, Gabriele, +2 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Two paths towards precision at a very high energy lepton collider
Journal of High Energy Physics, 2021 We illustrate the potential of a very high energy lepton collider (from 10 to 30 TeV center of mass energy) to explore new physics indirectly in the vector boson fusion double Higgs production process and in direct diboson production at high energy ...
Dario Buttazzo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source