Results 41 to 50 of about 2,578 (284)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Ontology of Compositeness Within Quantum Field Theory [PDF]
In this work, we attempt to define a notion of compositeness compatible with Quantum Field Theory. Considering the analytic properties of the S-matrix, we conclude that there is no satisfactory definition of compositeness compatible with Quantum Field ...
Peterken, Toby
core +5 more sources
, 1992 USING THE EXPERIMENTAL DATA OF THE DELPHI DETECTOR AT LEP-CERN WE PERFORM AN ELECTRON COMPOSITENESS STUDY. THE STUDY IS BASED ON THE DEVIATIONS INDUCED BY THEFOUR FERMION CONTACT INTERACTIONS OF THE ELECTRON CONSTITUENTS IN THE DIFFERENTIAL CROSS-SECTION
Μπελτράν, Πέτρος
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Flavour anomalies and (fundamental) partial compositeness
, 2018 International audienceSeveral measurements of B-meson decay observables show deviations from Standard Model (SM) predictions, some of them hinting at violation of lepton flavour universality (LFU).
Stangl, Peter
core +1 more source
Underlying gauge-fermion models of compositeness [PDF]
, 2022 We review recent advances in the construction of models of compositeness using four-dimensional gauge theories with fermionic matter. We discuss the group theory data needed to fulfill the basic phenomenological requirements and we touch upon the main ...
Ferretti, Gabriele,, Ferretti, Gabriele
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source