Results 61 to 70 of about 885,061 (318)

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Chiral Hierarchies, Compositeness and the Renormalization Group [PDF]

, 1993
A wide class of models involve the fine--tuning of significant hierarchies between a strong--coupling ``compositeness'' scale, and a low energy dynamical symmetry breaking scale.
A. J. Paterson, B. Grinstein, C. T. Hill, C. T. Hill, C. T. Hill, C. T. Hill, C. T. Hill, Christopher T. Hill, Dirk-U. Jungnickel, H. Yamagishi, M. E. Machacek, M. E. Machacek, R. S. Chivukula, R. S. Chivukula, S. Coleman, S. Martin, S. Martin, T. Appelquist, T. Eguchi, T. Eliot, T. Takeuchi, V. A. Miranski, V. A. Miransky, V. A. Miransky, W. A. Bardeen, William A. Bardeen, Y. Nambu, Y. Nambu, Y. Shen   +28 more
core   +2 more sources

Holomorphy of Composition [PDF]

Bulletin of the American Mathematical Society, 1974
Abstract In this paper we study the holomorphy, with respect to various locally convex topologies, of the composition map ϕ : (f,g) ∈ X × Y → gof E Z of holomorphic functions between Banach spaces E and F, and F and G. If X includes all the constant functions, then ϕ will not be holomorphic when Y is the space of entire functions from F to G ...
openaire   +4 more sources

Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague, Kristin Engelstad, Yue Ge, Amber Tucker, Shufang Li, Jasim Uddin, Ziwei Zhao, John L. P. Thompson, Michio Hirano   +8 more
wiley   +1 more source

CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body composition, nutritional status, and metabolic biomarkers in PD. Methods CSF cf‐mtDNA levels, defined as the
Yasuaki Mizutani, Tsuyoshi Nakai, Yasuhiro Maeda, Reiko Ohdake, Atsuhiro Higashi, Toshiki Maeda, Ryunosuke Nagao, Sayuri Shima, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Hirohisa Watanabe   +11 more
wiley   +1 more source

Top Theories [PDF]

, 1999
As the most recently discovered and heaviest quark, the top presents us with theoretical challenges. How are we to understand its properties within the larger effort to explain the origins of electroweak and flavor symmetry breaking ? This talk discusses
Simmons, E. H.
core   +2 more sources

Composite Dirac Neutrinos

, 2011
We present a mechanism that naturally produces light Dirac neutrinos. The basic idea is that the right-handed neutrinos are composite. Any realistic composite model must involve `hidden flavor' chiral symmetries.
A Kusenko, C Amsler, C Giunti, CT Hill, DA Demir, Dean J. Robinson, G Gersdorff von, G Marshall, G ’t Hooft, H Davoudiasl, I Gogoladze, KR Dienes, LJ Hall, LM Krauss, M Loewenstein, M-C Chen, ME Peskin, N Arkani-Hamed, N Arkani-Hamed, O Napoly, P Langacker, P Langacker, PQ Hung, RD Peccei, S Abel, S Antusch, S Dimopoulos, S Dodelson, S Raby, S Weinberg, T Asaka, T Asaka, T Gherghetta, T Okui, Y Grossman, Y Grossman, Yuval Grossman   +36 more
core   +1 more source

Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu, Jiyeon Son, Lindsay McAlpine, Elizabeth L. S. Walker, Megan Dahl, Emily Song, Sugeidy Ferreira Brito, Katelyn Kavak, Kaho Onomichi, Amit Bar‐Or, Christopher Perrone, Claire S. Riley, Bianca Weinstock‐Guttman, Philip L. De Jager, Erin E. Longbrake, Zongqi Xia   +15 more
wiley   +1 more source

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source