Results 201 to 210 of about 8,615,782 (346)

Effects of altering CpG dinucleotide composition in small DNA viruses

, 2020
Lisa Loew
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Association of physical and social neighbourhood environment with movement behaviours among schoolchildren: a compositional data analysis. [PDF]

Int J Behav Nutr Phys Act
Xing R, Rachele JN, Loh V, Dumuid D, Pedišić Ž.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Variation in cranial and caudal keel bone composition and its association with keel damage severity in laying hens. [PDF]

Poult Sci
Kurta K, Sallam M, Elmersson L, Enrich-Essvein T, Vias-Valera S, Gunnarsson S, Wall H, Dunn IC, de Koning DJ, Johnsson M, Rodriguez-Navarro AB.   +10 more
europepmc   +1 more source

Biofertilizers effects on some agromorphological parameters and harvest stage on nutrients composition of ginger (Zingiber officinale Rosc.) [PDF]

Tchiaze Ifoue Alice Virginie, Moo Marie Rosalie, Dongho Dongmo Fabrice Fabien, Ngueuleu Deuheula Armand, Tefouet Vaugelas Duthie, Inocent Gouado   +5 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Additions and Corrections

Natural Product Communications, 2012
Janne Rojas, Shirley Baldovino, Marietta Vizcaya, Luis B. Rojas, Antonio Morales   +4 more
doaj   +1 more source

Prognostic implications of body composition changes in patients with non-metastatic pancreatic adenocarcinoma treated with mFOLFIRINOX. [PDF]

Front Oncol
Lee JH, Ko Y, Na S, Kim KW, Yoon H, Yoo C, Kim KP, Kim TW, Jeong H, Kim SY.   +9 more
europepmc   +1 more source