Results 111 to 120 of about 741,288 (282)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Poincaré Inequalities for Composition Operators with Lφ-Norm

open access: yesAbstract and Applied Analysis, 2014
We establish the Poincaré-type inequalities for the composition of the homotopy operator, exterior derivative operator, and the projection operator with Lφ-norm applied to the nonhomogeneous A-harmonic equation in Lφ(Ω)-averaging domains.
Ru Fang
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri   +2 more
wiley   +1 more source

Norms of Composition Operators from Weighted Harmonic Bloch Spaces into Weighted Harmonic Zygmund Spaces

open access: yesJournal of Function Spaces
This article examines the norms of composition operators from the weighted harmonic Bloch space BHλ ...
Munirah Aljuaid, M. A. Bakhit
doaj   +1 more source

On the composition operator with variable integrability

open access: yesAIMS Mathematics
In this article, we considered a class of composition operators on Lebesgue spaces with variable exponents over metric measure spaces. Taking advantage of the compatibility between the metric-measurable structure and the regularity properties of the ...
Carlos F. Álvarez   +3 more
doaj   +1 more source

Weighted Composition Operators from Hardy to Zygmund Type Spaces

open access: yesAbstract and Applied Analysis, 2013
This paper aims at studying the boundedness and compactness of weighted composition operator between spaces of analytic functions. We characterize boundedness and compactness of the weighted composition operator from the Hardy spaces to the Zygmund ...
Shanli Ye, Zhengyuan Zhuo
doaj   +1 more source

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