Results 101 to 110 of about 62,935 (305)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Hermitian Weighted Composition Operators and Bergman Extremal Functions

open access: yes, 2017
Weighted composition operators have been related to products of composition operators and their adjoints and to isometries of Hardy spaces. In this paper, Hermitian weighted composition operators on weighted Hardy spaces of the unit disk are studied.
고응일
core   +1 more source

On the product of Toeplitz and composition operators on Fock-Sobolev spaces

open access: yes四川大学学报. 自然科学版, 2021
We characterize the boundedness of the product of Toeplitz and composition operators for two polynomials symbols on Fock-Sobolev spaces. We also consider the commutativity of Toeplitz and composition operator, and obtain several necessary and sufficient ...
QIN Jie, WANG Xiao-Feng
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A Linear Composition Operator on the Bloch Space

open access: yesMathematics
Let n∈N0, ψ be an analytic self-map on D and u be an analytic function on D. The single operator Du,ψn acting on various spaces of analytic functions has been a subject of investigation for many years.
Xiangling Zhu, Qinghua Hu
doaj   +1 more source

Some results on composition operators on ℓ2

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1979
A necessary and sufficient condition for a bounded operator to be a composition operator is investigated in this paper. Normal, quasi-hyponormal, paranormal composition operators are characterised.
R. K. Singh, D. K. Gupta, B. S. Komal
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

On Invertible Weighted Composition Operator on Hardy Space H^2

open access: yes, 2016
In this paper we study the product of a weighted composition operator , with the adjoint of a weighted composition operator , ∗ on the Hardy space ℍ2 . The order of the product give rise to different cases .
H. Abood, Eiman, A. H., Mohammed
core  

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