Results 81 to 90 of about 478,994 (322)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Some results on composition operators on ℓ2
International Journal of Mathematics and Mathematical Sciences, 1979 A necessary and sufficient condition for a bounded operator to be a composition operator is investigated in this paper. Normal, quasi-hyponormal, paranormal composition operators are characterised.
R. K. Singh, D. K. Gupta, B. S. Komal
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Composition operators and closures of Dirichlet type spaces in logarithmic Bloch-type spaces [PDF]
, 2020 Liqin Zhang
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Linear Composition Operator on the Bloch Space
MathematicsLet n∈N0, ψ be an analytic self-map on D and u be an analytic function on D. The single operator Du,ψn acting on various spaces of analytic functions has been a subject of investigation for many years.
Xiangling Zhu, Qinghua Hu
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Integral type operators from normal weighted Bloch spaces to QT,S spaces
Journal of Hebei University of Science and Technology, 2016 Operator theory is an important research content of the analytic function space theory. The discussion of simultaneous operator and function space is an effective way to study operator and function space.
Yongyi GU, Wenjun YUAN, Fanning MENG
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Kitai's Criterion for composition operators
Journal of Mathematical Analysis and ApplicationsWe present a general and natural framework to study the dynamics of composition operators on spaces of measurable functions, in which we then reconsider the characterizations for hypercyclic and mixing composition operators obtained by Bayart, Darji and Pires.
Daniel Gomes, Karl-G. Grosse-Erdmann
openaire +3 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source