Results 71 to 80 of about 2,962,628 (305)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Dynamics of composition operators on weighted Banach Spaces of holomorphic functionsweighted Banach space

四川大学学报. 自然科学版, 2017
In this paper, we discuss the disjoint hypercyclicity of linear composition on the weighted Banach spaces.Moreover,according to the difference of the analytic maps,we obtain a sufficient condition for the disjoint hypercyclicity and disjoint ...
HU Xiao-He
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Isometric and Closed-Range Composition Operators between Bloch-Type Spaces

International Journal of Mathematics and Mathematical Sciences, 2011
We present an overview of the known results describing the isometric and closed-range composition operators on different types of holomorphic function spaces.
Nina Zorboska
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Spectra of Some Composition Operators

Journal of Functional Analysis, 1994
If \(\mathcal H\) is a Hilbert space of holomorphic functions on the unit ball \(B_ N\) in \({\mathbf C}^ N\) and \(\phi\) is a non-constant holomorphic map of the unit ball into itself, the composition operator \(C_ \varphi\) is the operator on \(\mathcal H\) defined by \(C_ \varphi f= f\circ \varphi\). The authors give spectral properties for bounded
Cowen, C.C., Maccluer, B.D.
openaire   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A New Essential Norm Estimate of Composition Operators from Weighted Bloch Space into -Bloch Spaces [PDF]

, 2013
Let be any weight function defined on the unit disk and let be an analytic self-map of . In the present paper, we show that the essential norm of composition operator mapping from the weighted Bloch space to -Bloch space is comparable to where for ,
René E. Castillo, Edixon M. Rojas, Julio C. Ramos-Fernández, Li, Songxiao, Zhou, Jizhen, Qian, Ruishen   +5 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source