Results 181 to 190 of about 2,190,509 (268)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Phytochemical Identification of Major Compounds From Leaves of Nicotiana glauca Graham (Solanaceae) Extracts Using LC-ESI-MS/MS and Molecular Docking Analysis. [PDF]

J Mass Spectrom
WardaTrifa, Akkal S, Perruchon O, Schmitz I, Afonso C, Elomri A, Huseynova A, Kekeçoğlu M, Menacer R.   +8 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

How to Perform a Tracer Displacement BRET Assay for the TRPML1 Ion Channel. [PDF]

Bio Protoc
Cunha MR, Catta-Preta CMC, Massirer KB, Couñago RM.   +3 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Overcoming Docetaxel Resistance in Prostate Cancer by Targeting Cell Cycle Progression with Narciclasine-Based Compounds. [PDF]

ACS Omega
Silva Machado R, S Gomes K, B Farias A, Meneses Araújo N, Barbosa Chanes G, Pinto Dias LM, Zaia Franco Ferreira B, Lopes CC, Rubio IGS, Moreira Simabuco F, G G Rando D, Pequeno Monteiro H, Garcia Erustes A, Smaili SS, Ryffel D, Sarlah D, Cerchiaro G, Lago JHG, Tamura RE.   +18 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Staudinger reaction: a versatile synthetic tool for the construction of β-lactams, heterocycles, and functional organic molecules. [PDF]

RSC Adv
Mughal EU, Naeem N, Iftikhar L, Shabnam, Afzaal A, Alrafai HA, Zaki MEA, Sadiq A, Fathalla M.   +8 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Design, synthesis, molecular docking and anticancer activity of novel <i>N</i>-(4-(chlorodifluoromethoxy)phenyl)-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine-5-carboxamide derivatives. [PDF]

RSC Adv
Bhise PB, Bhise SB, Dasgupta S, Nandy A, Gundla R, Gurska S, Dzubak P, Hajdúch M, Das V, Thopate SR, Badadhe PV.   +10 more
europepmc   +1 more source