Results 241 to 250 of about 1,969,026 (318)

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3-NS5 Interaction Inhibitors. [PDF]

ChemMedChem
Janáč J, Drahorád J, Harvalík J, Horáčková T, Brinker M, Loregian A, Brancale A, Mercorelli B, Cuřínová P.   +8 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Advancements in the manufacturing routes for the synthesis of marketed PARP inhibitors. [PDF]

RSC Adv
Rani D, Plebanski M, Chatterjee T.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Structure-Guided Optimization of Novel Inhibitors of <i>Plasmodium</i> Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites. [PDF]

J Med Chem
Forte B, Bellany F, Campbell PS, Chemi G, Dawson A, Anderson M, Aniweh Y, Burkhard AY, Aguiar ACC, Churchyard A, Cooper CA, Dos Santos Ferreira A, Famodimu MT, Fang FG, Hu X, Huijs T, Baud D, Jansen C, Jiménez Díaz MB, Bonnert R, Boyd S, Crespo-Fernández B, Mitasev B, Montagna S, Mok S, Murugesan D, Narwal SK, Norcross NR, Okombo J, Park H, Peet C, Pereira DB, Post JM, Reader J, Riley J, Robinson DA, Shinkyo R, Simeons FRC, Simpson L, Smith A, Smith D, Striepen J, Teles CBG, van der Laak R, Uhlemann AC, Vantaux A, Wilson C, Witkowski B, Wood G, Yeo T, Zuccotto F, Angulo-Barturen I, Baum J, Bolscher JM, Guido RVC, Birkholtz LM, Delves MJ, Dembele L, Fidock DA, Gamo FJ, Kyle DE, Maher SP, Popovici J, Walpole C, Gusovsky F, Willis PA, Read KD, Gilbert IH, Baragaña B.   +68 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Age-of-acquisition affects object recognition and compound word identification: Evidence from visual duration thresholds and progressive demasking. [PDF]

Atten Percept Psychophys
Elsherif MM, Kirkden RD, Catling J.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Heterologous Expression Unexpectedly Activates the Host Cryptic Genes in <i>Aspergillus nidulans</i> and Enables the Discovery of Novel Natural Products. [PDF]

J Fungi (Basel)
Liu C, Hao Y, Qi S, Bai J.
europepmc   +1 more source

A phenotypic <i>in vitro</i> assay of mouse oocyte maturation identifies reversible blockers of meiotic progression for non-hormonal contraceptive discovery. [PDF]

Hum Reprod Open
Pea J, Zhu Y, Lee HC, Haky LR, Proudfoot J, Nelson R, Duncan FE.   +6 more
europepmc   +1 more source