Results 51 to 60 of about 952,046 (252)

Optimization of substituted 6-salicyl-4-anilinoquinazoline derivatives as dual EGFR/HER2 tyrosine kinase inhibitors.

PLoS ONE, 2013
4-Anilinoquinazolines as an important class of protein kinase inhibitor are widely investigated for epidermal growth factor receptor (EGFR) tyrosine kinase or epidermal growth factor receptor 2 (HER2) inhibition.
Dong-Dong Li, Ya-Juan Qin, Jian Sun, Jing-Ran Li, Fei Fang, Qian-Ru Du, Yong Qian, Hai-Bin Gong, Hai-Liang Zhu   +8 more
doaj   +1 more source

Five New Limonoids from Peels of Satsuma Orange (Citrus reticulata)

Molecules, 2017
Five new: 21,23-dihydro-21-hydroxy-23-oxonomilin (1), 21,23-dihydro-23-methoxy-21-oxonomilin (2), 21,23-dihydro-21-hydroxy-23-oxonomilinic acid methyl ester (3), 21,23-dihydro-23-methoxy-21-oxolimonin (4), and 21,23-dihydro-21-oxolimonin (5), and seven ...
Takashi Kikuchi, Yasuaki Ueno, Yoshino Hamada, Chika Furukawa, Takako Fujimoto, Takeshi Yamada, Reiko Tanaka   +6 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Effect of compound 21 on food intake in KK-Ay mice.

, 2013
Animals were fed normal standard diet for 2 weeks. Values are mean±SEM of 15 to 20 mice for each group. C21, compound 21.
Tomas Unger (298899), Kana Tsukuda (298894), Kousei Ohshima (298887), Masatsugu Horiuchi (298901), Ulrike M. Steckelings (298898), Masaki Mogi (298889), Akiyoshi Ogimoto (298896), Björn Dahlöf (298897), Fei Jing (298892), Jun Iwanami (298893), Li-Juan Min (298895), Jitsuo Higaki (298900)   +11 more
core   +1 more source

Donation for students from the compound collections [PDF]

, 2020
Pekan, 21 October 2020 - The Security Division, Universiti Malaysia Pahang (UMP), handed over a contribution of RM1,956 as part of the payment of compounds and fines due to violating traffic rules and road discipline on campus for ...
Nor Salwana, Mohammad Idris
core  

Effect of Different Fertilizer Types on Quality of Foxtail Millet under Low Nitrogen Conditions

Plants
In order to clarify the effect of different fertilizers on foxtail millet quality under low nitrogen conditions, we used JGNo.21 and LZGNo.2 as experimental materials and set up five treatments, including non-fertilization, nitrogen, phosphorus, compound,
Tingting Zheng, Shu Wang, Mengyao Wang, Jiao Mao, Yuanmeng Xu, Jiangling Ren, Yuhan Liu, Sichen Liu, Zhijun Qiao, Xiaoning Cao   +9 more
doaj   +1 more source

Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes

BMC Medicine, 2023
Background Compound epidermal growth factor receptor (EGFR) mutations are less responsive to tyrosine kinase inhibitors (TKIs) than single EGFR mutations in non-small cell lung cancer (NSCLC).
Weixin Zhao, Ailing Song, Yang Xu, Qian Wu, Cuicui Liu, Jiani C. Yin, Qiuxiang Ou, Xue Wu, Yang Shao, Xinmin Zhao   +9 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Verteilter Verstärker MMIC mit 21 dB Verstärkung und 90 Ghz Bandbreite basierend auf InP-DHBTs

, 2022
S.67-70This paper reports a state-of-the-art distributed amplifier intended for use in 100 Gbit/s optical communication systems (Ethernet). Using an InP DHBT technology, exhibiting cut-off frequency values of more than 275 GHz for both fT and fmax, the ...
Driad, Rachid, Weimann, G., Makon, R.E., Schneider, K.   +3 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source