Results 31 to 40 of about 952,046 (252)

Efficacy and resistance of EGFR-TKIs for first-line treatment for compound EGFR mutations positive non-small cell lung cancer

陆军军医大学学报, 2022
Objective To observe the characteristics of mutation patterns in patients with compound EGFR mutations in the same exon and their resistance to EGFR TKIs, and to explore the clinical features and survival benefits among these non-small cell lung cancer ...
GUAN Xuhui, GUAN Xuhui, LIN Xiaocheng, LIN Xiaocheng, YANG Jinji   +4 more
doaj   +1 more source

German compound splitting using the compound productivity of morphemes [PDF]

, 2018
In this work, we present a novel compound splitting method for German by capturing the compound productivity of morphemes. We use a giga web corpus to create a lexicon and decompose noun compounds by computing the probabilities of compound elements as ...
Sugisaki, Kyoko, Tuggener, Don, Sugisaki, Kyoko; https://orcid.org/   +2 more
core   +1 more source

Compound activity records associated with original publications in ChEMBL 21

, 2016
<p>Provided are two sets of compound activity records (set 1 and set 2) that were traced back to original publications and assembled from ChEMBL release 21.
Bajorath, Jürgen (5133368), Hu, Ye (5199964), Bajorath, Jürgen, Hu, Ye   +3 more
core   +1 more source

Convolutional neural network based on SMILES representation of compounds for detecting chemical motif

BMC Bioinformatics, 2018
Background Previous studies have suggested deep learning to be a highly effective approach for screening lead compounds for new drugs. Several deep learning models have been developed by addressing the use of various kinds of fingerprints and graph ...
Maya Hirohara, Yutaka Saito, Yuki Koda, Kengo Sato, Yasubumi Sakakibara   +4 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

AT2R Activation Improves Wound Healing in a Preclinical Mouse Model

Biomedicines
Abnormal skin healing resulting in chronic wounds or hypertrophic scarring remains a major healthcare burden. Here, the antifibrotic angiotensin II type 2 receptor (AT2R) signaling pathway was modulated to determine its impact on cutaneous wound healing.
Julia M. Harrison, Edwin K. Leong, Natasha D. Osborne, Jean S. Marshall, Michael Bezuhly   +4 more
doaj   +1 more source

Effect of dietary supplemental compound probiotics on growth performance， intestinal barrier and immune function of broilers challenged with Clostridium perfringens

Siliao yanjiu, 2023
The study was conducted to investigate the effect of dietary supplemental compound probiotics on growth performance, intestinal barrier and immune function of Clostridium perfringens infected broilers.
LIU Zhi-peng, NIU Jun-long, FANG Bi-jun, WANG Si-tian, ZHANG Zheng-fan, GUO Shuang-shuang, DING Bin-ying   +6 more
doaj  

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hydrogen bonds between compound 18 and compound 21 with NS2B/NS3pro that found with at least 0.1% occupancy throughout 70ns simulation time.

, 2019
Hydrogen bonds between compound 18 and compound 21 with NS2B/NS3pro that found with at least 0.1% occupancy throughout 70ns simulation time.
Ezatul Ezleen Kamarulzaman (6260978), Nornisah Mohamed (1375221), Noorsaadah Abd Rahman (550281), Maywan Hariono (6260969), Rohana Yusof (401395), Ros Fatihah Roslim (6260972), Sy Bing Choi (4408978), Habibah A. Wahab (1425556), Mei Lan Tan (678491), Shatrah Othman (6260981), Mohamed Sufian Nawi (6260975), Rozana Othman (677989)   +11 more
core   +1 more source

Study on application effect of complex enzyme preparations in low-protein diets of broilers

Siliao yanjiu, 2023
The experiment was conducted to investigate the effect of adding complex enzyme preparation in low protein diet on growth performance, serum biochemical indices, intestinal morphology and immune organ indices of broilers.
LIU Sheng-jun, WANG Shuai-jie, ZHANG Cheng-jie, ZHANG Wei, FU Da-bo, WANG Xiao-liang, ZHOU Ming, ZHOU Ying   +7 more
doaj