Results 21 to 30 of about 985,715 (260)

2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication

Molecules, 2020
The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase (RT)-associated ribonuclease H (RNase H) function is a promising drug ...
Angela Corona, Valentina Onnis, Claudia Del Vecchio, Francesca Esposito, Yung-Chi Cheng, Enzo Tramontano   +5 more
doaj   +1 more source

AT2R Activation Improves Wound Healing in a Preclinical Mouse Model

Biomedicines
Abnormal skin healing resulting in chronic wounds or hypertrophic scarring remains a major healthcare burden. Here, the antifibrotic angiotensin II type 2 receptor (AT2R) signaling pathway was modulated to determine its impact on cutaneous wound healing.
Julia M. Harrison, Edwin K. Leong, Natasha D. Osborne, Jean S. Marshall, Michael Bezuhly   +4 more
doaj   +1 more source

Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro

Molecules, 2018
New amphiphilic 1,4-DHP derivative C12-Man-Q with remoted cationic moieties at positions 2 and 6 was synthesised to study DNA delivery activity. The results were compared with data obtained for cationic 1,4-DHP derivative D19, which is known to be the ...
Gunita Apsite, Irena Timofejeva, Aleksandra Vezane, Brigita Vigante, Martins Rucins, Arkadij Sobolev, Mara Plotniece, Karlis Pajuste, Tatjana Kozlovska, Aiva Plotniece   +9 more
doaj   +1 more source

Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates

Acta Pharmaceutica Sinica B, 2020
FTY720 and IMMH002, prodrugs for sphingosine-1-phosphate receptor 1 (S1P1) agonists, show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats.
Qiong Xiao, Minwan Hu, Si Chen, Yifan Tang, Zeyu Shi, Jing Jin, Jinping Hu, Ping Xie, Dali Yin   +8 more
doaj   +1 more source

Efficacy and resistance of EGFR-TKIs for first-line treatment for compound EGFR mutations positive non-small cell lung cancer

陆军军医大学学报, 2022
Objective To observe the characteristics of mutation patterns in patients with compound EGFR mutations in the same exon and their resistance to EGFR TKIs, and to explore the clinical features and survival benefits among these non-small cell lung cancer ...
GUAN Xuhui, GUAN Xuhui, LIN Xiaocheng, LIN Xiaocheng, YANG Jinji   +4 more
doaj   +1 more source

Convolutional neural network based on SMILES representation of compounds for detecting chemical motif

BMC Bioinformatics, 2018
Background Previous studies have suggested deep learning to be a highly effective approach for screening lead compounds for new drugs. Several deep learning models have been developed by addressing the use of various kinds of fingerprints and graph ...
Maya Hirohara, Yutaka Saito, Yuki Koda, Kengo Sato, Yasubumi Sakakibara   +4 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Effect of dietary supplemental compound probiotics on growth performance， intestinal barrier and immune function of broilers challenged with Clostridium perfringens

Siliao yanjiu, 2023
The study was conducted to investigate the effect of dietary supplemental compound probiotics on growth performance, intestinal barrier and immune function of Clostridium perfringens infected broilers.
LIU Zhi-peng, NIU Jun-long, FANG Bi-jun, WANG Si-tian, ZHANG Zheng-fan, GUO Shuang-shuang, DING Bin-ying   +6 more
doaj  

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Study on application effect of complex enzyme preparations in low-protein diets of broilers

Siliao yanjiu, 2023
The experiment was conducted to investigate the effect of adding complex enzyme preparation in low protein diet on growth performance, serum biochemical indices, intestinal morphology and immune organ indices of broilers.
LIU Sheng-jun, WANG Shuai-jie, ZHANG Cheng-jie, ZHANG Wei, FU Da-bo, WANG Xiao-liang, ZHOU Ming, ZHOU Ying   +7 more
doaj