Results 21 to 30 of about 952,046 (252)
Life, 2023 Background: Sustained microglial activation contributes to the development of post-stroke cognitive impairment (PSCI). Compound 21 (C21), an angiotensin II type 2 receptor agonist, has shown some neurovascular protection after stroke. This study aimed to
Abdulkarim Alshammari +7 more
doaj +1 more source
Two New Koumine-Type Indole Alkaloids from Gelsemium elegans Benth.
Molecules, 2013 Two new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth together with three known compounds.
Huanhuan Gao +4 more
doaj +1 more source
Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice. [PDF]
PLoS ONE, 2015 Neuropathic pain is common in peripheral nerve injury and often fails to respond to ordinary medication. Here, we investigated whether the two novel epigallocatechin-3-gallate (EGCG) polyphenolic derivatives, compound 23 and 30, reduce the neuropathic ...
Xavier Xifró +6 more
doaj +1 more source
Design and Synthesis of AMPK Activators and GDF15 Inducers
Molecules, 2023 Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activators to ...
Meijian Zhang +7 more
doaj +1 more source
Revista Ingenio, 2016 This document presents the identification of valves and flanged unions of a plant for the processing and transformation of hydrocarbons. The identification was carried out in order to monitor the elements (flanged joints and valves) according to the ...
Edwin Espinel Blanco +2 more
doaj +1 more source
Molecules, 2020 The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase (RT)-associated ribonuclease H (RNase H) function is a promising drug ...
Angela Corona +5 more
doaj +1 more source
Summarized synthetic scheme for synthesis of AK6 (compound 25) and E249 (compound 21).
, 2014 Summarized synthetic scheme for synthesis of AK6 (compound 25) and E249 (compound 21).
Oludotun A. Phillips (580133) +4 more
core +1 more source
Soft Array Surface-Changing Compound Eye
, 2021 The field-of-view (FOV) of compound eyes is an important index for performance evaluation. Most artificial compound eyes are optical, fabricated by imitating insect compound eyes with a fixed FOV that is difficult to adjust over a wide range.
Chuanshuai Hu +5 more
core +1 more source
Molecules, 2018 New amphiphilic 1,4-DHP derivative C12-Man-Q with remoted cationic moieties at positions 2 and 6 was synthesised to study DNA delivery activity. The results were compared with data obtained for cationic 1,4-DHP derivative D19, which is known to be the ...
Gunita Apsite +9 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2020 FTY720 and IMMH002, prodrugs for sphingosine-1-phosphate receptor 1 (S1P1) agonists, show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats.
Qiong Xiao +8 more
doaj +1 more source