Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice [PDF]
eLife, 2023 Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors.
Janine Traut +12 more
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Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats. [PDF]
PLoS ONE, 2020 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience. However, the first used ligands exhibited dose-dependent selectivity for their molecular target, leading to potential ...
Raphaël Goutaudier +3 more
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DREADD agonist compound 21 causes acute diuresis in wild-type mice [PDF]
Frontiers in PharmacologyThe targeted activation or inhibition of specific cell populations using chemogenetics allows the precise dissection of cellular signaling and function.
Bryce MacIver +3 more
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Renoprotective effects of compound 21 and empagliflozin in L-Name-induced hypertensive rats [PDF]
BMC UrologyBackground This study investigated the renoprotective effects of compound 21 (C21) and empagliflozin (EMPA) individually and in combination in an Nω-Nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rat model. The objective of this study was to
Onural Ozhan +6 more
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Compound 21 Attenuates Isoflurane-Induced Injury in Neonatal Rat Hippocampal Neurons and Primary Rat Neuronal Cells by Upregulating METTL3 [PDF]
Journal of Inflammation ResearchYaping Shen,1,2,* Yijiu Wu,3,* Hai Zhuang,4 Zhumei Chen,5 Qiong Zhang,5 Peixin Li,5 Jing Wang,3 Zhi Huang,1 Qingfan Zeng3,5 1Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, People’s ...
Shen Y +8 more
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Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury [PDF]
Journal of Inflammation Research, 2018 Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Hendrik Steinkraus, Burkhard Lachmann, Claudia D Spies, David Schwaiberger Department of Anesthesiology and Operative Intensive Care Medicine, Charité – University Medicine Berlin ...
Menk M +6 more
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Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy [PDF]
Scientific ReportsGlioblastoma multiform (GBM) is the most deadly type of primary CNS tumor and is linked to dysregulation of the CDK4/6 pathway, poor prognosis, and high rate of post-surgical recurrence.
Muhammad Umer Khan +5 more
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Ginsenosides in Panax genus and their biosynthesis
Acta Pharmaceutica Sinica B, 2021 Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, stems,
Maoqi Hou +3 more
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Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21
Pharmaceuticals, 2021 Blockers of angiotensin II type 1 receptor (AT1R) exert antidepressant-like effects by indirectly facilitating the activation of the angiotensin II type 2 receptor (AT2R), which leads to increased surface expression and transactivation of tropomyosin ...
Liina Laukkanen +5 more
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Antimalarial dihydrochalcone isolated from Artocarpus sericicarpus Jarret leaves and in silico investigation against falcipain-2 protein [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Aims: To investigate the potential antimalarial plant belonging to the Artocarpus genus, Artocarpus sericicarpus, and isolate the antimalarial active compound from leaves extract.
Lidya Tumewu +12 more
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