Results 1 to 10 of about 939,531 (119)

Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice [PDF]

eLife, 2023
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity of DREADDs in neuroscience and sleep research, potential effects of the DREADD actuator clozapine-N-oxide (CNO) on sleep have never ...
Jose Prius Mengual, Janine Traut, Elise J Meijer, Laura E McKillop, Hannah Alfonsa, Anna Hoerder-Suabedissen, Seo Ho Song, Kristoffer D Fehér, Dieter Riemann, Zoltan Molnar, Colin J Akerman, Vladyslav V Vyazovskiy, Lukas B Krone   +12 more
openaire   +6 more sources

Acute In Vivo Administration of Compound 21 Stimulates Akt and ERK1/2 Phosphorylation in Mouse Heart and Adipose Tissue. [PDF]

Int J Mol Sci, 2023
Quiroga DT, Narvaéz Pardo JA, Zubiría MG, Barrales B, Muñoz MC, Giovambattista A, Dominici FP.   +6 more
europepmc   +1 more source

Potential nephroprotective effects of angiotensin II type 2 receptor agonist Compound 21 in renal ischemia-reperfusion injury. [PDF]

J Med Life, 2023
Kadhim LF, Gany SN, Qassam H, Hadi NR, Kadhim S.   +4 more
europepmc   +1 more source

Compound 21, a Direct AT2R Agonist, Induces IL-10 and Inhibits Inflammation in Mice Following Traumatic Brain Injury. [PDF]

Neuromolecular Med, 2022
Ismael S, Ishrat T.
europepmc   +1 more source

Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats. [PDF]

PLoS One, 2020
Goutaudier R, Coizet V, Carcenac C, Carnicella S.   +3 more
europepmc   +1 more source

21-Derivatives of Compound S, Cortisone, and Hydrocortisone. [PDF]

Acta Chemica Scandinavica, 1955
Poul Borrevang, Lars Odin
openaire   +1 more source

Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization. [PDF]

Transl Stroke Res, 2020
Jackson L, Dong G, Althomali W, Sayed MA, Eldahshan W, Baban B, Johnson MH, Filosa J, Fagan SC, Ergul A.   +9 more
europepmc   +1 more source

Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice. [PDF]

Sci Rep, 2019
Jendryka M, Palchaudhuri M, Ursu D, van der Veen B, Liss B, Kätzel D, Nissen W, Pekcec A.   +7 more
europepmc   +1 more source

Effects of compound 21, a non‑peptide angiotensin II type 2 receptor agonist, on general anesthesia‑induced cerebral injury in neonatal rats. [PDF]

Mol Med Rep, 2018
Yong J, Yan L, Wang J, Xiao H, Zeng Q.
europepmc   +1 more source

Renoprotective effects of compound 21 and empagliflozin in L-Name-induced hypertensive rats. [PDF]

BMC Urol
Ozhan O, Colak M, Karaca E, Dogru F, Kucukakcali Z, Acet A, Parlakpinar H.   +6 more
europepmc   +1 more source