Results 111 to 120 of about 504 (195)

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

open access: yesChemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup   +5 more
wiley   +1 more source

Reverse Engineering and Performance Evaluation of a Pump Impeller Fabricated With Additive Manufacturing

open access: yesChemie Ingenieur Technik, EarlyView.
This study explores the process chain for reverse engineering and additive manufacturing of a water pump impeller in a process plant. Key aspects include digital twin creation, CAD redesign, material certification, Hirtisation postprocessing, and performance testing. Insights highlight iterative design for improved precision and reliability.
Michael Stadler   +3 more
wiley   +1 more source

Double Sided Traction Force Microscopy: A Method to Confine Cells for Physiologically Relevant Force Measurements

open access: yesCytoskeleton, EarlyView.
ABSTRACT In this paper we describe a technique to make a confined environment of variable stiffness that is suitable for high‐resolution live‐cell imaging. This versatile and adaptable technique enables cell confinement between soft elastic surfaces made from polyacrylamide gels.
Alexia Caillier, Patrick W. Oakes
wiley   +1 more source

Semi‐analytical solution for the stability of deep vertical shaft considering time‐dependent rock‐structure interaction

open access: yesDeep Underground Science and Engineering, EarlyView.
A novel cavity contraction solution and multilayer shaft wall model were developed to analyze deep shaft stability, considering rock viscosity, support structures, and water pressure, with successful validation through a Hulusu Coal Mine case study.
Bin Chen   +5 more
wiley   +1 more source

Gaborlet‐guided sparse filtering: A novel intelligent method for lithology identification by vibration signals while drilling

open access: yesDeep Underground Science and Engineering, EarlyView.
The flowchart illustrates rock specimen testing, vibration signal acquisition, and feature extraction with Gaborlet and sparse filtering for classification. Abstract Traditional lithology identification methods mainly rely on core sampling and well‐logging data.
Jian Hao   +5 more
wiley   +1 more source

Mechanism and disaster control new technology of strong ground pressure manifestation in ultra‐large mining face

open access: yesDeep Underground Science and Engineering, EarlyView.
In response to the problem of strong mining pressure manifestation along the goaf roadway in a thick coal seam mining area, this study uses a new type of combined blasting roof cutting technology to effectively control the manifestation and deformation of mining pressure along the goaf roadway.
Xiaoding Xu   +6 more
wiley   +1 more source

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