Results 101 to 110 of about 348,445 (260)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Spatially Compounding Drought‐Flood Events Are Favored by Atmospheric Blocking Over Europe

Water Resources Research
Droughts and floods can occur simultaneously at the continental scale, resulting in impacts from both excess and deficit of water at the same time. Such spatially compounding drought‐flood events can result in contrasting water management challenges ...
Manuela I. Brunner, Magdalena Mittermeier, Bailey Anderson, Dominik Büeler, Eduardo Muñoz‐Castro   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Compounding Impacts of Extreme Climate Events on European Birds Under Climate Change

Conservation Letters
When multiple simultaneous or successive extreme climatic events occur, compound impacts can follow, where the effects of one event worsen the impacts of another.
Henry Häkkinen, Nathalie Pettorelli
doaj   +1 more source

A review on the resilience of temperate forests to extreme precipitation and wind events

Frontiers in Forests and Global Change
Temperate forests which provide vital ecosystem functions through the provision of timber resources, carbon sequestration, and recreational value are increasingly affected by extreme weather events, with wind and precipitation extremes (drought and ...
Tijs Kuzee, Tommaso Locatelli, Suzanne Robinson, Mike P. Perks, Mike P. Perks, Paul J. Burgess, Abdou Khouakhi   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Compound weather systems of cyclones, fronts and thunderstorms in global reanalysis

Environmental Research Letters
Many studies have examined the climatology of individual types of impactful weather systems such as cyclones, fronts and thunderstorms, with some recent studies also considering compound weather systems where more than one type occur at the same time and
Andrew J Dowdy, Jennifer L Catto, Hongsheng Wang   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Spatially Compounding Drought Events in Brazil

Water Resources Research
AbstractSpatially compounding drought events affect multiple locations simultaneously, severely affecting food, water, energy, human health, and infrastructure sectors. Despite the cascading impacts and challenges compound droughts impose on society, we still lack an in‐depth understanding of spatially connected drought occurrences.
Gabriela C. Gesualdo, Marcos R. Benso, Eduardo M. Mendiondo, Manuela I. Brunner   +3 more
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source