Results 101 to 110 of about 939,391 (232)

Compound Fault Diagnosis for Gearbox based on Variational ModeDecomposition and Correlated Kurtosis

Jixie chuandong, 2019
Aiming at the characteristics of non-linear, non-stationary, multi-noise and multi-fault signals of the compound fault signal in gearboxes, a compound fault diagnosis method for gearboxes based on variational mode decomposition and correlated kurtosis is
Zhang Xin, Zhao Jianmin, Tong Xiaofan, Song Weixing, Ni Xianglong   +4 more
doaj  

Dynamic Characteristics of Gear System Under Compound Fault of Tooth Root Crack and Bearing Outer Ring

Machines
Research on single faults like tooth root cracks and bearing outer ring failures is well-established. However, existing studies often replace the actual crack propagation path with a simplified linear crack model, neglecting the variation in stress ...
Yu Bai, Hong Jiang, Xiangfeng Zhang, Zhen Lei, Wenhan Huang, Zhijie Zhu, Chaochao Cui   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of Blade Faults on the Performance Characteristics of a Vertical Axis Wind Turbine [PDF]

, 2013
Due to the diminishing reserves of fossil fuels and increased pollution from exploitation of these fuels, the world is focusing on the renewable energy sources. Wind is being considered as one of the prime next generation energy sources.
Park, Kyooseon, Asim, Taimoor, Mishra, Rakesh   +2 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Dynamic Analysis of Transmission Gears With Combined Tooth Wear and Root Crack Failures

Shock and Vibration
Compound faults present a considerable challenge in fault diagnosis for gear transmission systems, as existing studies predominantly focus on individual failure modes.
Xiaoning Bai, Qi Gong, Yadong Zhao, Qing Xia   +3 more
doaj   +1 more source

An Adaptive Deconvolution Method with Improve Enhanced Envelope Spectrum and Its Application for Bearing Fault Feature Extraction

Sensors
To address the problem that complex bearing faults are coupled to each other, and the difficulty of diagnosis increases, an improved envelope spectrum–maximum second-order cyclostationary blind deconvolution (IES-CYCBD) method is proposed to realize the ...
Fengxia He, Chuansheng Zheng, Chao Pang, Chengying Zhao, Mingyang Yang, Yunpeng Zhu, Zhong Luo, Haitao Luo, Lei Li, Haotian Jiang   +9 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source