Results 211 to 220 of about 250,961 (302)

A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology. [PDF]

Pharmaceutics
Secretan PH, Annereau M, Do B.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Synergistic Enhancement of Visible-Light-Driven Photocatalytic H₂O₂ Production over g-C₃N₄/ZnCdS by Zn Vacancies and Heterointerface Engineering. [PDF]

Nanomaterials (Basel)
Wang Z, Yan W, Wei Y, Xu J, Xie Y, Chen Y, Yan X.   +6 more
europepmc   +1 more source

How does ultrafast imaging affect shear wave visualization? [PDF]

, 2016
Caenen, Annette, Ekroll, Ingvild, Pernot, Mathieu, Segers, Patrick, Shcherbakova, Darya, Swillens, Abigaïl   +5 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Empowering pharmacists in Canada's drug shortage response. [PDF]

Can Pharm J (Ott)
Zhang PC, Tadrous M.
europepmc   +1 more source

Costs Paid With Other People\u27s Money - Inaugural Address, A.A. Sommer, Jr. Annual Lecture in Corporate, Securities & Financial Law [PDF]

, 2001
Levitt, Arthur
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Rethinking infrastructure design from component failure to systemic resilience. [PDF]

Nat Commun
Dulin S, Mitoulis SA, Bredikhin A, Treyz E, Leung B, Dykes J, Karpeles O, Gurav S, Karhunen A, Linkov I.   +9 more
europepmc   +1 more source