Results 101 to 110 of about 9,370 (298)

How Compounding Pharmacies Fill Critical Gaps in Pediatric Drug Development Processes: Suggested Regulatory Changes to Meet Future Challenges. [PDF]

Children (Basel), 2022
MacArthur RB, Ashworth LD, Zhan K, Parrish RH.   +3 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Iowa Board of Pharmacy News, September 2015 [PDF]

, 2015
The Iowa Board of Pharmacy News is published by the Iowa Board of Pharmacy and the National Association of Boards of Pharmacy Foundation, Inc, to promote compliance of pharmacy and drug ...

core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Paediatric orodispersible lozenges produced by moulding process: quality and stability control

Pharmaceutical Technology in Hospital Pharmacy
Active pharmaceutical ingredients for paediatric patients are formulated at hospital pharmacy services and compounding pharmacies when they are not commercially available.
Magariños-Triviño María, Monzón-Rodríguez Cecilia, Caiazzo-Lima José Andrés, Santoveña-Estévez Ana, Fariña José B.   +4 more
doaj   +1 more source

Comparative Analysis of Resilience by Supply Network Structure [PDF]

, 2015
This research applies Kim, et al.’s (2015) supply network structure archetypes to case data related to two disruptions in three industries in Brazil. A total of seven supply networks were studied, through in-depth interviews and archival documents.
Bradaschia, Marcelo, Flynn, Barbara B., Paulo, Sao, Siegler, Janaina, Vargas, Fundacao Getulio   +4 more
core  

Relationship between performance barriers and pharmacist competency towards the implementation of an expanded public health pharmacy role. [PDF]

, 2015
OBJECTIVE: The objective of this study was to examine the relationship between performance barriers and competency, and implementation of an expanded public health role for community pharmacists.
Kirby, Brian P, Mathialagan, Amuthaganesh, Mathialagan, Saravanabavan, Nagalinggam, Preesha   +3 more
core   +2 more sources

Frequency, nature and determinants of pharmacy compounded medicines in Dutch community pharmacies

Pharmacy World & Science, 2003
To examine the frequency, nature and determinants of pharmacy compounded medicines in Dutch community pharmacies.A prospective nested case-control study comparing prescriptions for pharmacy compounded medicines (cases) with non-pharmacy compounded medicines (controls) was carried out in 79 Dutch community pharmacies.
Buurma, H., de Smet, P.G.A.M., van den Hoff, O.P., Sysling, H., Storimans, M.J., Egberts, A.C.G.   +5 more
openaire   +4 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source