Results 61 to 70 of about 62,936 (308)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Safety and efficacy of the feed additives cobalt(II) acetate tetrahydrate, cobalt(II) carbonate, cobalt(II) carbonate hydroxide (2:3) monohydrate and cobalt(II) sulphate heptahydrate for bovines with a functional rumen, equidae, lagomorphs, rodents, herbivore reptiles, zoo mammals and camelids (Regal B.V.)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of cobalt(II) acetate tetrahydrate, cobalt(II) carbonate, cobalt(II) carbonate hydroxide (2:3) monohydrate and cobalt(II) sulphate
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Maria Bastos, Fernando Ramos, Georges Bories, Jürgen Gropp, Alberto Mantovani, Jaume Galobart, Anna Dioni, Orsolya Holczknecht, Fabiola Pizzo, Maria Vittoria Vettori, Alberto Navarro‐Villa   +27 more
doaj   +1 more source

Safety and efficacy of selenium compounds (E8) as feed additives for all animal species: Sodium selenite, based on a dossier submitted by Todini and Co SpA

EFSA Journal, 2016
Selenium is an essential trace element for vertebrates, involved in a series of vital metabolic functions. Sodium selenite is a safe and efficacious source of selenium for all animal species/categories.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Revisiting copper and zinc in end-stage renal disease patients

Pediatria Polska
Numerous research projects have discovered how trace elements affect people with end-stage renal disease (ESRD). Thus, understanding the mechanism of action and the potential treatment options requires research into the chemical compounds that have an ...
Maha Abd Sahab, Basim Abd Al-Raheem, Khalid Farouk, Hussein Al-Hakeim, Maha Abd Al-Sahab   +4 more
doaj   +1 more source

Safety and efficacy of manganese hydroxychloride as feed additive for all animal species

EFSA Journal, 2016
The additive under assessment, manganese hydroxychloride, contains ≥ 45% manganese (Mn). Manganese hydroxychloride is a safe source of manganese for all target species when used up to the maximum level of total manganese in complete feed authorised in ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Scientific Opinion on safety and efficacy of zinc compounds (E6) as feed additive for all animal species: Zinc oxide, based on a dossier submitted by Grillo Zinkoxid GmbH/EMFEMA [PDF]

EFSA Journal, 2012
Zinc oxide is a safe source of zinc for all animal species and no concerns for consumer safety are expected from the use of zinc oxide in animal nutrition, considering the maximum contents for total zinc in feedingstuffs set by EU legislation. Zinc oxide
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Study on metal accumulation in aquatic plants of Cuciurgan cooling reservoir

E3S Web of Conferences, 2013
The biomass of plants from the Cuciurgan cooling reservoir of the Moldovan Thermal Power Plant is dependent on the reservoir thermofication and bore considerable modifications.
Zubcov E., Biletchi L., Philipenko E., Ungureanu L.   +3 more
doaj   +1 more source

Scientific Opinion on the safety and efficacy of iodine compounds (E2) as feed additives for all animal species: calcium iodate anhydrous, based on a dossier submitted by Calibre Europe SPRL/BVBA [PDF]

EFSA Journal, 2013
Calcium iodate anhydrous is considered a safe source of iodine for all animal species/categories when used up to the currently authorised maximum content of total iodine in complete feed, with the exception of horses and dogs, for which maximum tolerated
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source