Results 1 to 10 of about 193,784 (268)

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Molecular Brain, 2022
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression / neuroticism ...
Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen, Feng Zhang   +9 more
doaj   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

Molecular Brain, 2021
Objective To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. Methods The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS).
Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia, Feng Zhang   +8 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Dynamic and Stable Core Microbiota Assist Plants in Enriching Selenium and Reducing Cadmium Absorption

Advanced Science
Rhizosphere microbiome is crucial for regulating rhizosphere complex nutrient dynamics. However, mechanisms by which plants regulate rhizosphere microbes to manage nutrient availability under coexisting beneficial and harmful elements remain unclear ...
Zheng Lei, Hua Zhang, Wenju Liu, Jiandong Sheng, Huan Zhang, Yin Wang, Yanni Tang, Huaxing Wang, Cuicui Ding, Wanqi Qiao, Yonghui Zhu, Guoyin Yang, Yihan Zhang, Zhuoyi Liu, Nanyu Zhou, Chengxiao Hu, Xiaohu Zhao   +16 more
doaj   +1 more source

Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

Arthritis Research & Therapy, 2017
Background Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease. Little is known about the potential role of DNA methylation in the pathogenesis of AS. This study was undertaken to explore the potential role of DNA methylation in the
Jiangcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo, Feng Zhang   +8 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort

Bone & Joint Research, 2021
Aims: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made.
Bolun Cheng, Yan Wen, Xuena Yang, Shiqiang Cheng, Li Liu, Xiaomeng Chu, Jing Ye, Chujun Liang, Yao Yao, Yumeng Jia, Feng Zhang   +10 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source