Results 1 to 10 of about 1,047 (156)

The Long‐term Efficacy of Total Knee Arthroplasty on End‐stage Kashin–Beck Disease of the Knee in Highland Tibetan Areas Patients: A Retrospective Study with 10‐Year Follow‐up [PDF]

Orthopaedic Surgery
Objective Despite the established success of total knee arthroplasty (TKA) with end‐stage osteoarthritis, there is a notable scarcity of research on its long‐term outcomes in individuals suffering from end‐stage Kashin–Beck disease (KBD).
Haocheng Sun, Yahao Lai, Zichuan Ding, Yongrui Cai, Zeyu Luo, Zongke Zhou   +5 more
doaj   +3 more sources

A blood-based four-gene diagnostic signature for Kashin–Beck disease revealed by multi-cohort transcriptomic analysis and machine learning [PDF]

Frontiers in Immunology
BackgroundKashin–Beck disease (KBD) is an endemic osteoarthropathy characterized by growth retardation and progressive joint degeneration. However, its systemic molecular features in peripheral blood remain incompletely understood.MethodsPeripheral blood
Minghui Guo, Minghui Guo, Kunkun Yang, Kunkun Yang, Shizhang Liu, Shizhang Liu, Zhengming Sun, Zhengming Sun, Xueyuan Wu, Xueyuan Wu, Xinpei Li, Xinpei Li, Yuchao Wang, Yuchao Wang, Xinke Zhu, Ming Ling, Ming Ling   +16 more
doaj   +2 more sources

Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin–Beck disease [PDF]

BMC Musculoskeletal Disorders, 2020
Background Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patients is limited.
Lei Yang, Dimiao Wang, Xiuxia Li, Hangjing Yuan, Hua Fang, Xiong Guo   +5 more
doaj   +2 more sources

Fungal contamination in barley and Kashin-Beck disease in Tibet [PDF]

Lancet, The, 1997
5First results showed that mesophilic fungal contaminations were significantly higher on barley grains stored in families with KBD (median 66% of grains infected) than in healthy families (median 43% of grains infected) (Kruskal-Wallis ...
C Suetens, F Begaux, Eric Haubruge
exaly   +4 more sources

Long-term outcomes of arthroscopic debridement of the knee in adults with Kashin–Beck disease: an 18-year follow-up [PDF]

Journal of International Medical Research, 2021
Objective Kashin–Beck disease (KBD) is an endemic degenerative joint disease with a high disability rate. We retrospectively evaluated the 18-year clinical follow-up outcomes of adult patients with KBD who underwent arthroscopic debridement for knee ...
Zhan-Kui Jin, Cui-Xiang Xu, Xiang-Hui Dong, Ming Ling, Ming Chen, Zhi Yi, Shi-Zhang Liu, Xue-Yuan Wu, Zheng-Ming Sun, Yan-Hai Chang   +9 more
doaj   +2 more sources

Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population [PDF]

Open Medicine
Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (
He Na, Hong Aiwen, Zhao Kun, Zhang Zhefan, Wang Shengli, Jia Yaofei   +5 more
doaj   +2 more sources

A comparative metabolomic analysis reveals the metabolic variations among cartilage of Kashin-Beck disease and osteoarthritis [PDF]

Bone & Joint Research
Aims: The metabolic variations between the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) remain largely unknown. Our study aimed to address this by conducting a comparative analysis of the metabolic profiles present in the cartilage of ...
Hong Chang, Li Liu, Qingping Zhang, Gangyao Xu, Jianpeng Wang, Ping Chen, Cheng Li, Xianni Guo, Zhengjun Yang, Feng Zhang   +9 more
doaj   +2 more sources

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. [PDF]

PLoS ONE, 2018
Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively.
Wei Lian, Hui Liu, QuanQuan Song, Yun Qi Liu, Li Yan Sun, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +12 more
doaj   +1 more source

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. [PDF]

PLoS Genetics, 2009
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia.
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik   +6 more
doaj   +1 more source

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

Journal of Orthopaedic Surgery and Research, 2019
Background Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA).
Quan Quan Song, Li Yan Sun, Chun Hui Li, Yu Jiao Liu, Si Lu Cui, Yun Qi Liu, Yan Hong Cao, Jun Rui Pei, Yue Wang, Wei Lian, Zhe Jiao, Qing Deng, Jun Yu   +12 more
doaj   +1 more source