The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease [PDF]
Bone & Joint Research, 2020 Aims: Kashin-Beck disease (KBD) is a kind of chronic osteochondropathy, thought to be caused by environmental risk factors such as T-2 toxin. However, the exact aetiology of KBD remains unclear.
Mei Ma +7 more
doaj +4 more sources
A study on atypical Kashin–Beck disease: an endemic ankle arthritis [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background To study the epidemiological characteristics of atypical Kashin–Beck disease cases without characteristic hand lesions such as interphalangeal joint enlargement and brachydactyly and the characteristics of ankle joint lesions.
Fang Qi +4 more
doaj +2 more sources
Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease [PDF]
Frontiers in Genetics, 2022 The purpose of this study was clarify the relationship between the differential expression of cyclins CCNB1 and CCNG1 and chondrocyte damage in Kashin-Beck disease. Systematic review and high-throughput sequencing of chondrocytes derived from Kashin-Beck
Kaidiriye Setiwalidi +20 more
doaj +2 more sources
Untargeted Metabolomics Approach Correlated Enniatin B Mycotoxin Presence in Cereals with Kashin–Beck Disease Endemic Regions of China [PDF]
Toxins, 2023 Kashin–Beck disease (KBD) is a multifactorial endemic disease that only occurs in specific Asian areas. Mycotoxin contamination, especially from the Fusarium spp., has been considered as one of the environmental risk factors that could provoke ...
Danlei Sun +7 more
doaj +2 more sources
Detection of selenoprotein transcriptome in chondrocytes of patients with Kashin–Beck disease [PDF]
Frontiers in Cell and Developmental Biology, 2023 Background: Kashin–Beck disease (KBD) is a deformed osteochondral disease with a chronic progression that is restrictively distributed in eastern Siberia, North Korea, and some areas of China, and selenium deficiency has been identified as an important ...
Yi Gong +17 more
doaj +2 more sources
Combined Proximal Tibial Osteotomy for Adult Kashin–Beck Disease with Severe Varus Knee Osteoarthritis: Case Report and Literature Review [PDF]
Orthopaedic Surgery, 2022 Background Kashin–Beck disease (KBD) is an endemic, chronic osteoarthropathy that seriously affects joint function and can lead to severe knee deformity.
Yunfei Liu +4 more
doaj +2 more sources
ATAC-seq reveals the roles of chromatin accessibility in the chondrocytes of Kashin–Beck disease compared with primary osteoarthritis [PDF]
Frontiers in Genetics, 2023 Objective: This study aimed to investigate the roles of accessible chromatin in understanding the different pathogeneses between Kashin–Beck disease (KBD) and primary osteoarthritis (OA).Methods: Articular cartilages of KBD and OA patients were collected,
Sen Wang +5 more
doaj +2 more sources
Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents [PDF]
BMC Musculoskeletal Disorders, 2021 Introduction Diagnosing Kashin-Beck disease (KBD) involves damages to multiple joints and carries variable clinical symptoms, posing great challenge to the diagnosis of KBD for clinical practitioners.
Yanan Zhang +11 more
doaj +2 more sources
Identification of N-Glycoproteins of Knee Cartilage from Adult Osteoarthritis and Kashin-Beck Disease Based on Quantitative Glycoproteomics, Compared with Normal Control Cartilage [PDF]
Cells, 2022 Glycoproteins are involved in the development of many diseases, while the type and content of N-glycoproteins in the cartilage of osteoarthritis (OA) and Kashin–Beck disease (KBD) are still unclear.
Jing Han +10 more
doaj +2 more sources
Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment response in an endemic arthritis, Kashin-Beck disease [PDF]
Bone & Joint ResearchAims: To assess the alterations in cell-specific DNA methylation associated with chondroitin sulphate response using peripheral blood collected from Kashin-Beck disease (KBD) patients before initiation of chondroitin sulphate treatment.
Bolun Cheng +9 more
doaj +2 more sources