Results 21 to 30 of about 2,554 (202)

Long-term outcomes of arthroscopic debridement of the knee in adults with Kashin–Beck disease: an 18-year follow-up [PDF]

Journal of International Medical Research, 2021
Objective Kashin–Beck disease (KBD) is an endemic degenerative joint disease with a high disability rate. We retrospectively evaluated the 18-year clinical follow-up outcomes of adult patients with KBD who underwent arthroscopic debridement for knee ...
Zhan-Kui Jin, Cui-Xiang Xu, Xiang-Hui Dong, Ming Ling, Ming Chen, Zhi Yi, Shi-Zhang Liu, Xue-Yuan Wu, Zheng-Ming Sun, Yan-Hai Chang   +9 more
doaj   +2 more sources

Fungal contamination in barley and Kashin-Beck disease in Tibet [PDF]

The Lancet, 1997
5First results showed that mesophilic fungal contaminations were significantly higher on barley grains stored in families with KBD (median 66% of grains infected) than in healthy families (median 43% of grains infected) (Kruskal-Wallis ...
Chasseur, Camille, Suetens, Carl, Nolard, Nicole, Begaux, Françoise, Haubruge, Eric   +4 more
openaire   +5 more sources

The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease [PDF]

Bone & Joint Research, 2020
Aims: Kashin-Beck disease (KBD) is a kind of chronic osteochondropathy, thought to be caused by environmental risk factors such as T-2 toxin. However, the exact aetiology of KBD remains unclear.
Mei Ma, Xiao Liang, Xi Wang, Lu Zhang, Shiqiang Cheng, Xiong Guo, Feng Zhang, Yan Wen   +7 more
doaj   +2 more sources

Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population [PDF]

Open Medicine
Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (
He Na, Hong Aiwen, Zhao Kun, Zhang Zhefan, Wang Shengli, Jia Yaofei   +5 more
doaj   +2 more sources

A comparative metabolomic analysis reveals the metabolic variations among cartilage of Kashin-Beck disease and osteoarthritis [PDF]

Bone & Joint Research
Aims: The metabolic variations between the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) remain largely unknown. Our study aimed to address this by conducting a comparative analysis of the metabolic profiles present in the cartilage of ...
Hong Chang, Li Liu, Qingping Zhang, Gangyao Xu, Jianpeng Wang, Ping Chen, Cheng Li, Xianni Guo, Zhengjun Yang, Feng Zhang   +9 more
doaj   +2 more sources

Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin-Beck Disease. [PDF]

Depress Anxiety
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has been conducted in KBD patients. Methods: We conducted a field investigation in KBD areas in Northwest
Liu Y, Wen Y, Yang Z, Zhou R, Hui J, Li C, Xu G, Liu C, Liu H, Cheng B, Jia Y, Guo X, Zhang F.   +12 more
europepmc   +2 more sources

Transcriptome-wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin-Beck disease. [PDF]

J Cell Mol Med
Abstract Kashin‐Beck disease (KBD) is a chronic degenerative, disabling disease of the bones and joints and its exact aetiology and pathogenesis remain uncertain. This study is to investigate the role of m6A modification in the pathogenesis of KBD. Combined analysis of m6A MeRIP‐Seq and RNA‐Seq were used to analyse human peripheral blood samples from ...
Zhang Q, Yang X, Deng X, Niu H, Zhao Y, Wen J, Wang S, Liu H, Guo X, Wu C.   +9 more
europepmc   +2 more sources

Growth surveillance indices and Kashin-Beck Disease in children. [PDF]

J Med Life, 2022
Selenium, manganese, and calcium are necessary elements for maintaining normal growth and skeleton formation. Kashin-Beck disease mostly occurs in children, resulting in deformities, dwarfism, and disabilities. Selenium deficiency was considered a risk factor in China, while manganese was reportedly involved in it in Russia.
马玮娟 Ma Wei Juan.
europepmc   +3 more sources

Disease and Economic Burden of Kashin-Beck Disease - China, 2021‎. [PDF]

China CDC Wkly
Kashin-Beck disease (KBD) is a chronic and degenerative osteoarthropathy characterized by cartilage degeneration. It is an endemic disease that is highly prevalent among the Chinese population and poses a significant health risk.This is the first national report on the economic burden of KBD in China.
Cui S, Que W, Jiao Z, Deng Q, Zhang X, Cao Y, Liu N, Li A, Sowanou A, Li Z, Wang T, Li Y, Yu J, Pei J.   +13 more
europepmc   +3 more sources

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. [PDF]

PLoS Genetics, 2009
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia.
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik   +6 more
doaj   +1 more source