Hydrochemical characteristics of surface waters and their relationships to the Kashin–Beck Disease in Longzi County, Tibet [PDF]
Scientific Reports, 2022 Although previous studies have been reported between the Kashin–Beck Disease (KBD) epidemic and the hydrochemical characteristics of surface waters, the etiology of the disease remains unclear.
Xinjie Zha +3 more
doaj +2 more sources
Whole-exome sequencing for the identification of susceptibility genes of Kashin-Beck disease. [PDF]
PLoS ONE, 2014 ObjectiveTo identify and investigate the susceptibility genes of Kashin-Beck disease (KBD) in Chinese population.MethodsWhole-exome capturing and sequencing technology was used for the detection of genetic variations in 19 individuals from six families ...
Zhenxing Yang +14 more
doaj +2 more sources
Bone & Joint Research, 2020 Aims: Kashin-Beck disease (KBD) is a kind of chronic osteochondropathy, thought to be caused by environmental risk factors such as T-2 toxin. However, the exact aetiology of KBD remains unclear.
Mei Ma +7 more
doaj +3 more sources
Arthroscopic Ankle Arthrodesis for Treating Osteoarthritis in a Patient with Kashin-Beck Disease [PDF]
Case Reports in Medicine, 2014 Kashin-Beck disease (KBD) is an endemic degenerative osteoarthritis. Death of cartilage and growth plate is the pathologic feature; therefore, KBD involves skeletal deformity and often results in osteoarthritis.
Kenjiro Iwasa +6 more
doaj +2 more sources
Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population [PDF]
Open MedicineKashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (
He Na +5 more
doaj +2 more sources
A comparative metabolomic analysis reveals the metabolic variations among cartilage of Kashin-Beck disease and osteoarthritis [PDF]
Bone & Joint ResearchAims: The metabolic variations between the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) remain largely unknown. Our study aimed to address this by conducting a comparative analysis of the metabolic profiles present in the cartilage of ...
Hong Chang +9 more
doaj +2 more sources
The Long‐term Efficacy of Total Knee Arthroplasty on End‐stage Kashin–Beck Disease of the Knee in Highland Tibetan Areas Patients: A Retrospective Study with 10‐Year Follow‐up [PDF]
Orthopaedic SurgeryObjective Despite the established success of total knee arthroplasty (TKA) with end‐stage osteoarthritis, there is a notable scarcity of research on its long‐term outcomes in individuals suffering from end‐stage Kashin–Beck disease (KBD).
Haocheng Sun +5 more
doaj +2 more sources
PLoS ONE, 2013 BackgroundKashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD.ObjectiveTo investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699),
Lulin Huang +11 more
doaj +2 more sources
COMPREHENSIVE GEOCHEMICAL RESEARCH OF THE ENVIRONMENTAL COMPONENTS IN ENDEMIC AREAS OF TRANSBAIKALIA
Известия Томского политехнического университета: Инжиниринг георесурсов, 2021 The relevance of the research. Kashin–Beck disease, or Urov disease, is a classic example of endemic diseases. However, unlike other diseases, the cause of this one has not yet been determined.
Leonid P. Rikhvanov +15 more
doaj +1 more source
An in vitro model to study cartilage metabolism in Kashin-Beck disease [PDF]
Kashin-Beck disease is endemic chronic degenerative osteoarthropathy whose main pathological changes occur in the growth plate and articular cartilage of human limbs and joints, where it is manifest as cartilage degeneration and necrosis.
Hodgson, Paul David
core +5 more sources