Results 21 to 30 of about 1,061 (155)

Effects of selenium-mediated RUNX2 overexpression and its transcriptome alterations on Chondrocyte injury in Kashin Beck disease [PDF]

Frontiers in Cell and Developmental Biology
ObjectiveKashin-Beck disease (KBD) is a nutrition-related osteoarthropathy characterized by excessive apoptosis and matrix destruction. Micronutrient selenium (Se) deficiency is recognized as a major environmental risk factor.
Di Zhang, Di Zhang, Qiang Li, Xiaoli Yang, Yongmin Xiong, Shiquan Sun   +5 more
doaj   +2 more sources

A blood-based four-gene diagnostic signature for Kashin–Beck disease revealed by multi-cohort transcriptomic analysis and machine learning [PDF]

Frontiers in Immunology
BackgroundKashin–Beck disease (KBD) is an endemic osteoarthropathy characterized by growth retardation and progressive joint degeneration. However, its systemic molecular features in peripheral blood remain incompletely understood.MethodsPeripheral blood
Minghui Guo, Minghui Guo, Kunkun Yang, Kunkun Yang, Shizhang Liu, Shizhang Liu, Zhengming Sun, Zhengming Sun, Xueyuan Wu, Xueyuan Wu, Xinpei Li, Xinpei Li, Yuchao Wang, Yuchao Wang, Xinke Zhu, Ming Ling, Ming Ling   +16 more
doaj   +2 more sources

Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin–Beck disease [PDF]

BMC Musculoskeletal Disorders, 2020
Background Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patients is limited.
Lei Yang, Dimiao Wang, Xiuxia Li, Hangjing Yuan, Hua Fang, Xiong Guo   +5 more
doaj   +2 more sources

Long-term outcomes of arthroscopic debridement of the knee in adults with Kashin–Beck disease: an 18-year follow-up [PDF]

Journal of International Medical Research, 2021
Objective Kashin–Beck disease (KBD) is an endemic degenerative joint disease with a high disability rate. We retrospectively evaluated the 18-year clinical follow-up outcomes of adult patients with KBD who underwent arthroscopic debridement for knee ...
Zhan-Kui Jin, Cui-Xiang Xu, Xiang-Hui Dong, Ming Ling, Ming Chen, Zhi Yi, Shi-Zhang Liu, Xue-Yuan Wu, Zheng-Ming Sun, Yan-Hai Chang   +9 more
doaj   +2 more sources

Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population [PDF]

Open Medicine
Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (
He Na, Hong Aiwen, Zhao Kun, Zhang Zhefan, Wang Shengli, Jia Yaofei   +5 more
doaj   +2 more sources

A comparative metabolomic analysis reveals the metabolic variations among cartilage of Kashin-Beck disease and osteoarthritis [PDF]

Bone & Joint Research
Aims: The metabolic variations between the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) remain largely unknown. Our study aimed to address this by conducting a comparative analysis of the metabolic profiles present in the cartilage of ...
Hong Chang, Li Liu, Qingping Zhang, Gangyao Xu, Jianpeng Wang, Ping Chen, Cheng Li, Xianni Guo, Zhengjun Yang, Feng Zhang   +9 more
doaj   +2 more sources

Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin-Beck Disease. [PDF]

Depress Anxiety
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has been conducted in KBD patients. Methods: We conducted a field investigation in KBD areas in Northwest
Liu Y, Wen Y, Yang Z, Zhou R, Hui J, Li C, Xu G, Liu C, Liu H, Cheng B, Jia Y, Guo X, Zhang F.   +12 more
europepmc   +2 more sources

Transcriptome-wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin-Beck disease. [PDF]

J Cell Mol Med
Abstract Kashin‐Beck disease (KBD) is a chronic degenerative, disabling disease of the bones and joints and its exact aetiology and pathogenesis remain uncertain. This study is to investigate the role of m6A modification in the pathogenesis of KBD. Combined analysis of m6A MeRIP‐Seq and RNA‐Seq were used to analyse human peripheral blood samples from ...
Zhang Q, Yang X, Deng X, Niu H, Zhao Y, Wen J, Wang S, Liu H, Guo X, Wu C.   +9 more
europepmc   +2 more sources

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey. [PDF]

PLoS ONE, 2018
Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively.
Wei Lian, Hui Liu, QuanQuan Song, Yun Qi Liu, Li Yan Sun, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu   +12 more
doaj   +1 more source

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. [PDF]

PLoS Genetics, 2009
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia.
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik   +6 more
doaj   +1 more source