Results 41 to 50 of about 1,324,564 (290)

Mendelian randomization study of the relationship between blood and urine biomarkers and schizophrenia in the UK Biobank cohort

Communications Medicine
Background The identification of suitable biomarkers is of crucial clinical importance for the early diagnosis of treatment-resistant schizophrenia (TRS).
Bolun Cheng, Yunfeng Bai, Li Liu, Peilin Meng, Shiqiang Cheng, Xuena Yang, Chuyu Pan, Wenming Wei, Huan Liu, Yumeng Jia, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications

Annals of Medicine
Background Major depressive disorder (MDD) involves multifaceted pathologies including neurotransmission, neuroplasticity, inflammation, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction.
Yuping Li, Yucui Lu, Xianmei Lin, Lichun Zhao   +3 more
doaj   +1 more source

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Molecular Brain, 2022
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression / neuroticism ...
Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen, Feng Zhang   +9 more
doaj   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Monotone trace functions of several variables

, 2005
We investigate monotone operator functions of several variables under a trace or a trace-like functional. In particular, we prove the inequality \tau(x_1... x_n)\le\tau(y_1...
Hansen, Frank
core   +1 more source

Predictions for PP-wave string amplitudes from perturbative SYM [PDF]

, 2002
The role of general two-impurity multi-trace operators in the BMN correspondence is explored. Surprisingly, the anomalous dimensions of all two-impurity multi-trace BMN operators to order g_2^2\lambda' are completely determined in terms of single-trace ...
A. Santambrogio, C. Kristjansen, D. Berenstein, D. Vaman, D.J. Gross, H. Verlinde, I.S. Gradshteyn, J. Gomis, J. Pearson, J.-G. Zhou, M. Spradlin, M.-X. Huang, N. Beisert, N.R. Constable, N.R. Constable, R. Roiban, U. Gürsoy, Umut Gürsoy, W. Skiba   +18 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

Molecular Brain, 2021
Objective To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. Methods The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS).
Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia, Feng Zhang   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dynamic and Stable Core Microbiota Assist Plants in Enriching Selenium and Reducing Cadmium Absorption

Advanced Science
Rhizosphere microbiome is crucial for regulating rhizosphere complex nutrient dynamics. However, mechanisms by which plants regulate rhizosphere microbes to manage nutrient availability under coexisting beneficial and harmful elements remain unclear ...
Zheng Lei, Hua Zhang, Wenju Liu, Jiandong Sheng, Huan Zhang, Yin Wang, Yanni Tang, Huaxing Wang, Cuicui Ding, Wanqi Qiao, Yonghui Zhu, Guoyin Yang, Yihan Zhang, Zhuoyi Liu, Nanyu Zhou, Chengxiao Hu, Xiaohu Zhao   +16 more
doaj   +1 more source