Results 251 to 260 of about 31,094 (313)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Comparative performance evaluation of large language models in answering esophageal cancer-related questions: a multi-model assessment study. [PDF]

Front Digit Health
He Z, Zhao L, Li G, Wang J, Cai S, Tu P, Chen J, Wu J, Zhang J, Chen R, Huang Y, Pan X, Chen W.   +12 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Translation, cultural adaptation, and preliminary data evaluation of the Standardized Tool for the Assessment of Bruxism (STAB) and BruxScreen in Turkey. [PDF]

J Oral Facial Pain Headache
Bilgen B, Kaffaf MB, Şeşen P, Saygılı S, Özcan-Sezgin A, Dayan SÇ, Kurt H, Şakar O, Lobbezoo F, Manfredini D.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Psychometric properties of the sense of coherence scale: a cross-sectional study in Spain and Latin America. [PDF]

Sci Rep
Domínguez-Salas S, Rodríguez-Domínguez C, Escobar-Segovia K, Arcos-Romero AI, Gómez-Gómez I, Gómez-Salgado J.   +5 more
europepmc   +1 more source

Content validity assessment and modification of the FACE-Q craniofacial module for retinoblastoma survivors. [PDF]

PLoS One
Khan F, Noronha R, Ristevski I, Prunier M, Savoie G, Striowski A, Mallipatna AC, Wong-Riff KWY, Ali A, Dimaras H.   +9 more
europepmc   +1 more source

Impact of sense of coherence and social support on disease activity in Crohn's disease: a network analysis. [PDF]

Front Public Health
Han X, Liu J, Bu J, Wang Z, Chen Z, Wei M.   +5 more
europepmc   +1 more source

A hierarchical framework to evaluate the usability of smartphone health applications. [PDF]

Sci Rep
Siddique A, Sajjad Q, Algamdi SA, Shahzad B, Hussien JM.   +4 more
europepmc   +1 more source

Latent profiles and influencing factors of sense of coherence in patients with advanced cancer: A cross-sectional study. [PDF]

Asia Pac J Oncol Nurs
Huang Y, Xiong H, Tian X, Lai J, Zhou L, Chen L, Xiao W.   +6 more
europepmc   +1 more source