Molecular Oncology, EarlyView.We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin +10 more
wiley +1 more source
Longitudinal assessment of pragmatic and cognitive decay in healthy aging, and interplay with subjective cognitive decline and cognitive reserve. [PDF]
Sci RepGabbatore I +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Using eye movements, electrodermal activities, and heart rates to predict different types of cognitive load during reading with background music. [PDF]
Sci RepQue Y, Zheng Y, Hsiao JH, Hu X.
europepmc +1 more source
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
A functional systems view on neural tracking of natural speech. [PDF]
Front Syst NeurosciRogachev A, Sysoeva O.
europepmc +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Reading comprehension in L1 and L2 readers: neurocomputational mechanisms revealed through large language models. [PDF]
NPJ Sci LearnGu C, Nastase SA, Zada Z, Li P.
europepmc +1 more source
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Application of a hybrid virtual-physical teaching model integrating mixed reality and 3D printing in clinical joint orthopedic education. [PDF]
Front SurgWang H, Xu A, Hua W, Ye Z, Lu L.
europepmc +1 more source