Results 201 to 210 of about 793,323 (271)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A SWOT analysis of translanguaging in healthcare education: overcoming language barriers for future professionals. [PDF]

BMC Med Educ
Alasmari M, Alaqlobi O.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

The role of working memory for learning with context-personalized tasks in elementary school. [PDF]

Front Psychol
Laufs AK, Meyer A, Krüger M, Kempert S.
europepmc   +1 more source

[Proteomics: a comprehensive approach].

Anales de pediatria (Barcelona, Spain : 2003), 2014
A, Jara, J J, Kopchick
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

English-focused CL-HAMC with contrastive learning and hierarchical attention for multiple-choice reading comprehension. [PDF]

Sci Rep
Ji L, Yao L, Xu W.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Speech speed in audiovisual resources in the learning process of university students: a scoping review.

Codas
Silva KD, Alcantra Cruz PJ, Santos NFC, Jesus FVM, Behlau M, Almeida AA, Guedes-Granzotti RB.   +6 more
europepmc   +1 more source

Cognitive linguistics approach to the representation of knowledge contents in college English textbooks. [PDF]

Front Psychol
Zhang L, Mo Z.
europepmc   +1 more source