Results 81 to 90 of about 123,869 (292)

A Spectral Graphical Model Approach for Learning Brain Connectivity Network of Children's Narrative Comprehension [PDF]

, 2011
X. Sheldon Lin, Xiangxiang Meng, Prasanna Karunanayaka, Scott K. Holland   +3 more
openalex   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

The signal and comprehension approach: decoding and meaning building [PDF]

Journal of the National Council of Less Commonly Taught Languages, 2013
This paper discusses Egyptian colloquial Arabic connected speech as a listening problem. The paper proposes a modified approach for teaching listening: The Signal and Comprehension Approach.
Rajaa Aquil
doaj  

Liposome-A Comprehensive Approach for Researchers

, 2020
Bangham was first to develop these spherical-shaped nano-vesicles called liposomes in the early 1960s. Today, liposomes have emerged as crucial tools for bettering the delivery of drugs that majorly includes-antifungal drug, peptide hormones, enzymes, vaccines antimicrobial agents, drugs against cancer, and genetic materials.
Mamta N. Talati, Abhiram Kumar, Jyoti Joshi, Sandeep Vaidya, Mani Ram Sharma, Neeraj Kumar Chouhan   +5 more
openaire   +4 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Integration of Ontology and UML Class-Based Modelling for Knowledge Representation

Journal of Computing Research and Innovation, 2018
Program comprehension is an important process carried out involving much effort in software maintenance process. A key challenge to developers in program comprehension process is to comprehend a source code.
Rozita Kadar, Sharifah Mashita Syed-Mohamad, Putra Sumari, Nur 'Aini Abdul Rashid   +3 more
doaj  

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Reading strategies of primary school pupils in the Czech Republic [PDF]

Pedagogická Orientace, 2010
This article focuses on reading with comprehension – an activity of the readerwhich is seen as an interaction between the author and the recipient. In order tounderstand a text better, a reader may employ various techniques and strategies.
Veronika Najvarová
doaj