Results 81 to 90 of about 3,769,215 (284)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A New Process of Leaching Copper and Cobalt from Copper Cobalt Oxide Ore in DR Congo
Kuangchan zonghe liyongThis is an article in the field of metallurgical engineering. A copper cobalt ore Congo is an oxide ore with Cu 3.43% and Co 0.42% respectively. In this paper, the five stage cycle leaching process of leaching solution was used for the copper and cobalt ...
Yaohua CAO +4 more
doaj +1 more source
Aligning Capital With Mission: Lessons from the Annie E. Casey Foundation's Social Investment Program [PDF]
, 2016 The Annie E. Casey Foundation engaged InSight at Pacific Community Ventures to conduct the first comprehensive third-party evaluation of the SI Program, with research support from the Center for the Advancement of Social Entrepreneurship (CASE) at Duke ...
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
BMC Musculoskeletal DisordersBackground Various surgical techniques and conservative therapies are useful tools for treating proximal humerus fractures (PHFs), but it is important to understand how to properly utilize them.
Yun Zheng +5 more
doaj +1 more source
How Can We Help Our Grantees Strengthen Their Capacity for Evaluation? [PDF]
, 2015 Many of funders are already committed to evaluation as a tool to improve their programs and strategies, and are seeking ways to engage in this learning process in partnership with grantees.
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Development of Evaluation Systems – Evaluation Capacity Building in the Framework of the New Challenges of EU Structural Policy [PDF]
The paper presents the changing role of evaluation for public policies and the increasing importance of comprehensive evaluation systems for more effective and learning public institutions.
Jaime del Castillo, Silke Haarich
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source