Results 91 to 100 of about 137,196 (298)

Malnutrition in geriatric rehabilitation: Prevalence, patient outcomes, and criterion validity of the scored Patient-Generated Subjective Global Assessment and the Mini Nutritional Assessment [PDF]

, 2015
Background: Accurate identification and management of malnutrition is essential so that patient outcomes can be improved and resources used efficaciously.
Bauer, Judith, Isenring, Elizabeth, Marshall, Skye, Young, Adrienne   +3 more
core   +2 more sources

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

The 10-word learning task in the differential diagnosis of early Alzheimer's disease and elderly depression: a cross-sectional pilot study [PDF]

, 2010
Objectives: Identification of early Alzheimer's disease (AD) has become very important. Episodic memory tasks appear to have predictive power for indicating early AD. Deficits in encoding and storage processes that are characteristic of AD, however, must
D'Haenens, Ellen, De Deyn, Peter Paul, De Raedt, Rudi, Dierckx, Eva, Engelborghs, Sebastiaan, Ponjaert-Kristoffersen, Ingrid, Verte, Dominique   +6 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Factors Associated with Sustainability of Integrated Geriatric Health Post in Tabanan, Bali [PDF]

, 2018
Background: Much has been written recently about the need to develop more integrated care for older people. The term comprehensive geriatric assessment, is a form of integrated care for older people that is used to describe the practice of specialist ...
Peratiwi, I. (Indra ), Subratha, H. F. (Hesteria )   +1 more
core  

Reduced level of arousal and increased mortality in adult acute medical admissions: a systematic review and meta-analysis [PDF]

, 2017
Background Reduced level of arousal is commonly observed in medical admissions and may predict in-hospital mortality. Delirium and reduced level of arousal are closely related.
A Calle, A Liberati, A Nicolini, AE Jones, Alasdair M. J. MacLullich, American College of Surgeons Committee on Trauma, Amy Todd, BJ Naughton, BO Onadeko, C Barfod, C Chih-Hsun, CF Otieno, CN Sessler, David J. Stott, DJ Meagher, DK Kiely, E Francia, E Kaya, E. Wesley Ely, European Delirium Association and American Delirium Society, F Delahaye, G Bellelli, G Bellelli, G Teasdale, HA Conte, J Witlox, Jennifer K. Burton, JH Han, K Neufeld, K Oedorf, K Rockwood, MA Aslaner, ME Mikkelsen, MR Navinan, O Kruse, P Dutta, PK Myint, Review Manager (RevMan) [Computer program], RW Duckitt, S Rathour, S Zweig, Samantha Blackley, SK Inouye, Susan D. Shenkin, SY Kim, TA Jackson, TM Merz, VC Burch, W Hasegawa, Y Sakamoto, Y Yamauchi, Z Tieges, Zoë Tieges   +52 more
core   +4 more sources

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Screening methods for age-related hearing loss in older patients with cancer: A review of the literature [PDF]

, 2018
© 2018 by the authors. As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient's quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can
Boterberg, T., Cool, L., Debruyne, P.R., Lefebvre, T., Lycke, M., Schofield, Patricia, Van Eygen, K.   +6 more
core   +5 more sources

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

The Role of Artificial Intelligence in Medication Management for Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Artificial intelligence enhances medication management for older adults by improving adherence, personalizing treatment, and predicting risks. Despite benefits, challenges remain in usability, trust, ethics, and system integration. Successful adoption requires user‐centered design, ethical safeguards, and seamless healthcare integration to ensure safe,
Dipak Chandra Das, Moustaq Karim Khan Rony, Shovit Dutta, MD. Sami Al Zubair Zujbe, Tapan Bhattacharjee, Niloy Debnath, Shabbir Abdullah Maruf, Chowdhury Galib Mortuza, Farhana Rahman, Akash Das   +9 more
wiley   +1 more source