Results 81 to 90 of about 137,196 (298)

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

New horizons in the implementation and research of comprehensive geriatric assessment: knowing, doing and the “know-do” gap [PDF]

, 2016
In this paper we outline the relationship between the need to put existing applied health research knowledge into practice (the “know-do gap”) and the need to improve the evidence base (the “know gap”) with respect to the health care process used for ...
Conroy, Simon P., Gladman, John R.F., Gordon, Adam L., Ranhoff, Anette H.   +3 more
core   +2 more sources

Association of Comprehensive Geriatric Assessment’s Component and Sarcopenia in Elderly

Jurnal Penyakit Dalam Indonesia, 2019
Introduction. Sarcopenia is defined as a declined in skeletal muscle mass and strength along with its function may causes an increase in hospitalization, mortality, and health burden.
Diar Meitha Wardhana, Novira Widajanti, Jusri Ichwani   +2 more
doaj   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

‘Gaps, mishaps and overlaps’: nursing documentation: how does it affect care? [PDF]

, 2016
Introduction: Complete, accurate and relevant nursing documentation is essential for the multidisciplinary comprehensive geriatric assessment process which can improve older patient’s outcomes following a hospital admission.
Alzheimer’s Society, Ellis G, Francis R, Keenan GM, Liz Charalambous, Mason J, Nursing and Midwifery Council (NMC), Rose K, Sarah Goldberg   +8 more
core   +2 more sources

Aging-Related Concerns of People Living with HIV Referred for Geriatric Consultation

HIV/AIDS: Research and Palliative Care, 2021
Eugenia L Siegler,1 Jerad H Moxley,1 Marshall J Glesby2 1Division of Geriatrics and Palliative Care, Weill Cornell Medicine, New York, NY, 10065, USA; 2Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, 10065, USACorrespondence ...
Siegler EL, Moxley JH, Glesby MJ
doaj  

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

THE HIGH DIAGNOSTIC YIELD OF A GERIATRIC OUTPATIENT CLINIC [PDF]

, 2012
Objectives: To determine characteristics of older patients referred to a geriatric outpatient clinic; 2) to determine the prevalence of geriatric syndromes in this population; 3) to identify main recommendations made to referring primary care physicians.
Moret, F.
core  

An investigation of factors associated with depression in older adults

, 1989
As the population ages, there is a need for continued research into the etiology of geriatric depression and improved ways to detect individuals at risk for developing this disorder.
Mayhew, Katherine Mary
core   +1 more source