Results 41 to 50 of about 64,648 (216)

ABOUT THE BASICS OF COMPREHENSIVE GERIATRIC ASSESSMENT

Архивъ внутренней медицины, 2019
The article covers the principles of comprehensive geriatric assessment — an interdisciplinary diagnostic procedure aimed at developing a plan of treatment, long-term monitoring and support of an elderly person.
L. M. Farkhutdinova
doaj   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Consensus recommendation on Comprehensive Geriatric Assessment for elderly cancer patients from Peking Union Medical College Hospital [PDF]

Jichu yixue yu linchuang
In the context of an aging society, the number of elderly cancer patients is constantly increasing, and geriatric oncology has garnered significant attention in recent years.
WANG Qiumei, LI Xiaoyuan, KANG Lin, SUN Xiaohong, LI Hailong, DUAN Yanping, LIU Ying, GUAN Mei, ZHAO Lin
doaj   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Preventative approaches to falls and frailty

Osteoporosis and Sarcopenia
With increasing life expectancy, the aging population grows, leading to more age-related diseases. Among these, falls are a serious public health issue, as they cause disability in older adults and impose a significant burden both on caregivers and ...
Seiji Hashimoto, Tatsuya Hosoi, Mitsutaka Yakabe, Makoto Yunoki, Shoya Matsumoto, Yoshitaka Kase, Masashi Miyawaki, Masaki Ishii, Sumito Ogawa   +8 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

UCF Medical Student Comprehensive Geriatric Assessment

MedEdPORTAL, 2012
Almost one out of eight Americans is 65 years-of-age and older. This number will more than double during the next 30 years. The high number of seniors requires health care providers to focus their efforts on the long-term management of chronic medical ...
Adam Golden, Angela Berry, Maria L. Cannarozzi, Mariana B. Dangiolo   +3 more
doaj   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Effectiveness of three-week rehabilitation programs in improving mobility of patients with frailty syndrome: a subgroup analysis of the multicenter prospective study «POSTSCRIPTUM»

Российский журнал гериатрической медицины
BACKGROUND: The concept of frailty suggests the potential reversibility of this syndrome. Research indicated that geriatric rehabilitation programs aimed at maintaining mobility and functional independence reduce the frequency of repeated ...
O. N. Tkacheva, N. K. Runikhina, I. P. Malaya, N. V. Sharashkina, S. N. Lysenkov, M. S. Arefieva, E. E. Popov   +6 more
doaj   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source