Results 51 to 60 of about 637,518 (299)

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A Hybrid Compression-Absorption High Temperature Heat Pump Cycles for Industrial Waste Heat Recovery

Shanghai Jiaotong Daxue xuebao, 2021
Aimed at the problem that the conventional absorption heat pumps and compression heat pumps cannot take into account the temperature rise and efficiency, this paper proposes the use of a thermally-coupled hybrid compression-absorption heat pump to ...
AN Meiyan, ZHAO Xinrui, XU Zhenyuan, WANG Ruzhu
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Restoration by Compression [PDF]

IEEE Transactions on Signal Processing, 2018
In this paper we study the topic of signal restoration using complexity regularization, quantifying the compression bit-cost of the signal estimate. While complexity-regularized restoration is an established concept, solid practical methods were suggested only for the Gaussian denoising task, leaving more complicated restoration problems without a ...
Yehuda Dar, Michael Elad, Alfred M. Bruckstein   +2 more
openaire   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

MR-Compatible Compression Device for In-Vitro Evaluation of Biomechanical Properties of Cartilage

Journal of Biomechanical Science and Engineering, 2008
Objective: Purpose of the paper is to present and validate a device for cartilage compression for assessment of MR parameters (T1, T2, ADC) in cartilage explants before, during and after compression operating with novel features. Design: This device fits
Vladimir JURAS, Pavol SZOMOLANYI, Zuzana MAJDISOVA, Siegfried TRATTNIG   +3 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Video Data Compression by Progressive Iterative Approximation

International Journal of Interactive Multimedia and Artificial Intelligence, 2021
In the present paper, the B-spline curve is used for reducing the entropy of video data. We consider the color or luminance variations of a spatial position in a series of frames as input data points in Euclidean space R or R3.
M. J. Ebadi, A. Ebrahimi
doaj   +1 more source

On the Compressibility of Fluids [PDF]

Proceedings of the Royal Society of Edinburgh, 1895
The recent publication of the full results of Amagat's magnificent experiments has led me to make further comparisons with the empirical formula (originally suggested by the graphs of my Challenger work) which I have on several occasions brought before the Society:—viz.
openaire   +3 more sources