Results 51 to 60 of about 533,290 (269)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Acoustic properties and low strain rate behavior of different types of chocolate
International Journal of Food Properties, 2023 Five different chocolate types (i.e. extra dark, dark, milk, white, and ruby) were characterized and compared for the acoustical and textural characteristics.
Šárka Nedomová +7 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Ceramics, 2023 In this work, composites based on AA5049 aluminium alloy reinforced with multiwalled carbon nanotubes (CNTs) and multiwalled TiC-coated CNTs were prepared by powder metallurgy.
Artemiy V. Aborkin +3 more
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Литьë и металлургия, 2020 The mechanical properties of metals change temporarily or permanently under the influence of a high density electric current in the deformation zone. This phenomenon is called electroplasticity, and its use makes it possible to intensify the process of ...
D. V. Minko
doaj +1 more source
Resources, 2022 The development of this research work seeks to determine the mechanical behavior of the compacted mixture of pine sawdust and rice husk by varying the mass percentages of these biomasses obtained in briquettes, with the purpose of being marketed.
Oscar Araque +2 more
doaj +1 more source
Compressed Context Modeling for Text Compression
2011 Data Compression Conference, 2011 In text compression, statistical context modeling aims to construct a model to calculate the probability distribution of a character based upon its context. The order -- $k$ context of a symbol is defined as the string formed by its preceding $k$ symbols.
openaire +2 more sources